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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Name of Issuer)

(Title of Class of Securities)

(CUSIP Number)

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

X0202 SCHEDULE 13D/A 0001224962 XXXXXXXX LIVE 5 Common Stock, par value $0.0001 per share 06/30/2026 false 0001808805 63909J108 Nautilus Biotechnology, Inc. 2701 Eastlake Avenue East Seattle WA 98102 Perceptive Advisors LLC 646-205-5345 Alexander Rakitin, 51 Astor Place 10th Floor New York NY 10003 0001224962 N Perceptive Advisors LLC b AF Y DE 0 11634211 0 11634211 11634211 N 9.1 IA 0001164426 N Joseph Edelman b AF N X1 0 11634211 0 11634211 11634211 N 9.1 IN 0001249675 N Perceptive Life Sciences Master Fund, Ltd. b WC N E9 0 11468351 0 11468351 11468351 N 9.1 CO 0001890152 N C2 Life Sciences LLC b WC N E9 0 165860 0 165860 165860 N 0.1 CO Common Stock, par value $0.0001 per share Nautilus Biotechnology, Inc. 2701 Eastlake Avenue East Seattle WA 98102 Item 5(a) of the Schedule 13D is hereby amended and restated as follows: The information set forth in rows 11 and 13 of the cover pages to this Schedule 13D is incorporated by reference. The percentages set forth in row 13 are based on 127,255,223 shares of Common Stock outstanding as of July 24, 2026, as disclosed by the Issuer in its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on July 28, 2026. The information set forth in rows 7 through 10 of the cover pages to this Schedule 13D is incorporated by reference. Neither Perceptive Advisors LLC ( "Perceptive Advisors") nor Joseph Edelman ("Mr. Edelman") directly holds any Common Stock. Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") directly holds 11,468,351 shares of Common Stock, and C2 Life Sciences LLC ("C2") directly holds 165,860 shares of Common Stock. Perceptive Advisors serves as the investment manager to the Master Fund and C2. Mr. Edelman is the managing member of Perceptive Advisors. Perceptive Advisors LLC /s/ Joseph Edelman Joseph Edelman, Managing Member 08/14/2026 Joseph Edelman /s/ Joseph Edelman Joseph Edelman 08/14/2026 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman Joseph Edelman, Managing Member 08/14/2026 C2 Life Sciences LLC /s/ Joseph Edelman Joseph Edelman, Managing Member 08/14/2026