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Exhibit 32.2

CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER

PURSUANT TO 18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

I, Richard Scalzo, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to my knowledge, the Annual Report on Form 10-K of Crescent Biopharma, Inc. (the “Company”) for the fiscal year ended December 31, 2025, as filed with the Securities and Exchange Commission on the date hereof (the “Report”) (i), fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; (ii), and the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

/s/ Richard Scalzo
Richard Scalzo
Chief Financial Officer
(Principal Financial Officer)
February 26, 2026