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Exhibit 21.1

SUBSIDIARIES OF SELECT MEDICAL HOLDINGS CORPORATION

As of December 31, 2024

NAME						Jurisdiction of Organization
Actra Rehabilitation Associates, Inc.						Wisconsin
Acuity General Partner, LLC						Texas
Acuity Healthcare Holdings, Inc.						Delaware
Acuity Healthcare Management, LLC						Louisiana
Acuity Healthcare of Ohio, L.L.C.						Ohio
Acuity Healthcare, LP						Louisiana
Acuity Holdings, LLC						North Carolina
Acuity Hospital of New Jersey, L.L.C.						New Jersey
Acuity Specialty Hospital, LLC						New Jersey
Acuity Specialty Hospital—Ohio Valley, LP						Ohio
Advantage Rehabilitation Clinics, Inc.						Massachusetts
Alexandria Sports, Inc.						New York
Allevant Solutions, LLC						Delaware
American Transitional Hospitals, LLC						Delaware
Archer Rehabilitation, LLC						Delaware
Argosy Health, LLC						Delaware
Benchmark Acquisition Corp.						Delaware
Benchmark Medical Management Company						Delaware
Benchmark O&P Holdings, Inc.						Delaware
Benchmark Orthotics & Prosthetics, Inc.						Delaware
BHSM ES, Inc.						Delaware
BHSM Rehabilitation, LLC						Delaware
BIR JV, LLP						Texas
BIR Pinnacle GP, LLC						Texas
Blue Hen Physical Therapy, Inc.						Delaware
California Rehab Institute Medical Group						California
California Rehabilitation Institute, LLC						Delaware
Cape Prosthetics-Orthotics, Inc.						Missouri
Caritas Rehab Services, LLC						Kentucky
Carrollton Physical Therapy Clinic, Inc.						Texas
Central Iowa Physio, LLC						Iowa
Champion Sports Medicine Birmingham, LLC						Delaware
Cleveland Clinic Rehabilitation Hospitals, LLC						Delaware
CMC Ozarks Rehabilitation, LLC						Delaware
Coastal Virginia Rehabilitation, LLC						Virginia
CRI ES, Inc.						Delaware
Crowley Physical Therapy Clinic, Inc.						Louisiana
Dade Prosthetics & Orthotics, Inc.						Florida
DG Physical Therapy, P.C.						Massachusetts
Dignity Select Nevada, LLC						Delaware
Douglas Avery & Associates, Ltd.						Virginia
Duval Rehabilitation, LLC						Delaware
Eagle Rehab Corporation						Delaware
Eden Sports, Inc.						New York

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ES LTACH, LLC						Georgia
ES Rehabilitation, LLC						Georgia
ESOP Rehabilitation, LLC						Georgia
FC Select, LLC						Delaware
Fine, Bryant & Wah, Inc.						Maryland
Frederick Orthopedic Rehabilitation, Inc.						Maryland
Freedom Management Services, LLC						Pennsylvania
GH General, LLC						Texas
GH General-San Antonio, LLC						Texas
GlobalRehab — Fort Worth, LP						Texas
GlobalRehab — Scottsdale, LLC						Arizona
GlobalRehab, LP						Texas
GP Therapy, L.L.C.						Georgia
GR General-Scottsdale, LLC						Texas
Great Lakes Specialty Hospital—Hackley, LLC						Delaware
Great Lakes Specialty Hospital—Oak, LLC						Delaware
GRSH ES, Inc.						Delaware
Gulf Breeze Physical Therapy, Inc.						Florida
HealthWorks ES, Inc.						Delaware
Hospital Holdings Corporation						Delaware
Indiana Rehabilitation Services, LLC						Delaware
Indianapolis Physical Therapy and Sports Medicine, Inc.						Indiana
Integrity Physical Therapy, Inc.						Delaware
Intensiva Healthcare Corporation						Delaware
Intensiva Hospital of Greater St. Louis, Inc.						Missouri
ISH Northern Virginia, LLC						Delaware
Island Tree Physical Therapy, P.C.						Rhode Island
Jeffersontown Physical Therapy, LLC						Kentucky
Johnson Physical Therapy, Inc.						Ohio
Joyner Sportsmedicine Institute, Inc.						Pennsylvania
Kentucky Orthopedic Rehabilitation, LLC						Delaware
Kentucky Rehabilitation Services, Inc.						Kentucky
Kessler Hudson County Rehabilitation, LLC						Delaware
Kessler Institute for Rehabilitation, Inc.						New Jersey
Kessler Orthotic & Prosthetic Services, Inc.						Delaware
Kessler Pediatric Therapy, Inc.						Delaware
Kessler Professional Services, LLC						Delaware
Kessler Rehab Centers, Inc.						Delaware
Kessler Rehabilitation Corporation						Delaware
Kessler Rehabilitation Services, Inc.						New Jersey
Keystone Rehabilitation Systems of McMurray						Pennsylvania
Keystone Rehabilitation Systems, Inc.						Pennsylvania
KORT Kentuckiana, LLC						Delaware
KORT Rehabilitation at Home, LLC						Delaware

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Leesburg Sports, Inc.						New York
LifeBridge Sports Medicine and Rehabilitation, LLC						Maryland
LifeSigns Management, Inc.						Michigan
Long-Term Acute Care Hospital of Northern Virginia, LLC						Virginia
LTACH @ Riverside, LLC						Virginia
LTACH Morgantown, LLC						West Virginia
Madison Rehabilitation Center, Inc.						Connecticut
Matrix Healthcare Services, LLC						Delaware
Matrix Rehabilitation, Inc.						Delaware
Matrix Rehabilitation-Delaware, Inc.						Delaware
Matrix Rehabilitation-Georgia, Inc.						Delaware
Matrix Rehabilitation-Ohio, Inc.						Delaware
Matrix Rehabilitation-South Carolina, Inc.						Delaware
Matrix Rehabilitation-Texas, Inc.						Delaware
Metro Rehabilitation Services, Inc.						Michigan
Morris Area Rehabilitation Association, Inc.						New Jersey
North Dallas Physical Therapy Associates, Inc.						Texas
Northstar Health Service, Inc.						Delaware
NovaCare Occupational Health Services, Inc.						Delaware
NovaCare Outpatient Rehabilitation East, Inc.						Delaware
NovaCare Outpatient Rehabilitation, Inc.						Kansas
NovaCare Rehabilitation of Ohio, Inc.						Ohio
NSR ES, Inc.						Delaware
OHRH ES, Inc.						Delaware
OHRH Select, Inc.						Delaware
OHRH Subsidiaries, LLC						Delaware
OHRH, LLC						Ohio
OKC Rehabilitation, LLC						Delaware
Osprey Rehabilitation, LLC						Delaware
Osprey Urban Renewal, LLC						Delaware
OSR Louisiana, LLC						Delaware
OSR Property Ventures, LLC						Delaware
P&O Services, Inc.						Michigan
Pacific Rehabilitation & Sports Medicine, Inc.						Delaware
Penn State Hershey Rehabilitation, LLC						Delaware
PHS Physical Therapy, LLC						Delaware
PhysioKids, Inc.						Delaware
PhysioLink Corporation						Delaware
Physiotherapy Associates Holdings, Inc.						Delaware
Physiotherapy Associates NRH Rehab, LLC						Maryland
Physiotherapy Associates Union Rehab, LLC						Maryland
Physiotherapy Associates, Inc.						Michigan
Physiotherapy Corporation						Delaware
Physiotherapy-BMHI Holdings, Inc.						Delaware

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Pinnacle Health Select Rehabilitation, LLC						Delaware
PR Acquisition Corporation						California
Pro Active Therapy of North Carolina, Inc.						North Carolina
Pro Active Therapy of South Carolina, Inc.						South Carolina
Pro Active Therapy of Virginia, Inc.						Virginia
Pro Active Therapy, Inc.						North Carolina
Professional Rehab Associates, Inc.						Pennsylvania
Professional Therapeutic Services, Inc.						Ohio
Progressive Therapy, Services, Inc.						Ohio
PSHR Physical Therapy, LLC						Delaware
PTSMA, Inc.						Connecticut
R.S. Network, Inc.						Illinois
RCI (Michigan), Inc.						Delaware
RCI (WRS), LLC						Delaware
Regency Hospital Company of Macon, LLC						Delaware
Regency Hospital Company of Meridian, L.L.C.						Delaware
Regency Hospital Company of South Carolina, L.L.C.						Delaware
Regency Hospital Company, L.L.C.						Delaware
Regency Hospital of Atlanta, LLC						Delaware
Regency Hospital of Columbus, LLC						Delaware
Regency Hospital of Greenville, LLC						Delaware
Regency Hospital of Jackson, LLC						Delaware
Regency Hospital of Kansas City, LLC						Delaware
Regency Hospital of Minneapolis, LLC						Delaware
Regency Hospital of North Central Ohio, LLC						Delaware
Regency Hospital of Northwest Arkansas, LLC						Delaware
Regency Hospital of Northwest Indiana, LLC						Delaware
Regency Hospital of Rhode Island, LLC						Delaware
Regency Hospital of Rockford, LLC						Delaware
Regency Hospital of Southern Mississippi, LLC						Delaware
Regency Hospital of Toledo, LLC						Delaware
Regency Hospitals, LLC						Delaware
Regency Management Company, Inc.						Delaware
Rehab Associates of Jackson Hospital, LLC						Alabama
Rehab Associates, L.L.C.						Alabama
Rehab Colorado, LLC						Alabama
Rehab Hospital of Fort Wayne, LLC						Delaware
Rehab Missouri, LLC						Alabama
Rehab Provider Network of Colorado, Inc.						Colorado
Rehab Provider Network of New Mexico, Inc.						New Mexico
Rehab Provider Network of North Carolina, Inc.						North Carolina
Rehab Provider Network of South Carolina, Inc.						Delaware
Rehab Provider Network of Virginia, Inc.						Virginia
Rehab Provider Network—East I, Inc.						Delaware

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Rehab Provider Network—Indiana, Inc.						Indiana
Rehab Provider Network—Ohio, Inc.						Ohio
Rehab Provider Network—Pennsylvania, Inc.						Pennsylvania
Rehab Xcel, LLC						Alabama
RehabClinics (PTA), Inc.						Delaware
RehabClinics (SPT), Inc.						Delaware
RehabClinics, Inc.						Delaware
Rehabilitation Center of Washington, D.C., Inc.						Delaware
Rehabilitation Consultants, Inc.						Delaware
Rehabilitation Hospital of Vancouver, LLC						Delaware
Rehabilitation Institute of Denton, LLC						Delaware
RPN of NC, Inc.						Delaware
RSH Property Ventures, LLC						Delaware
Rush Specialty Hospital, LLC						Delaware
Rush-Select Holdings, LLC						Delaware
S.T.A.R.T., Inc.						Massachusetts
Saco Bay Orthopedic and Sports Physical Therapy, Inc.						Maine
SCRI, LLC						Delaware
Select Cleveland Hospitals, LLC						Delaware
Select Employment Services, Inc.						Delaware
Select Hospital Investors, LP						Delaware
Select Illinois Holdings, Inc.						Delaware
Select Kentuckiana, Inc.						Delaware
Select LifeCare Western Michigan, LLC						Delaware
Select Medical Corporation						Delaware
Select Medical International (US), Inc.						Delaware
Select Medical International Limited						Cyprus
Select Medical of Kentucky, Inc.						Delaware
Select Medical of Maryland, Inc.						Delaware
Select Medical of New York, Inc.						Delaware
Select Medical Patient Safety and Quality Institute, LLC						Delaware
Select Medical Property Ventures, LLC						Delaware
Select Medical Rehabilitation Clinics, Inc.						Delaware
Select NovaCare—PBG, Inc.						New York
Select NovaCare—PIT, Inc.						Arizona
Select Physical Therapy Holdings, Inc.						Delaware
Select Physical Therapy Network Services, Inc.						Delaware
Select Physical Therapy of Albuquerque, Ltd.						Alabama
Select Physical Therapy of Blue Springs Limited Partnership						Alabama
Select Physical Therapy of Colorado Springs Limited Partnership						Alabama
Select Physical Therapy of Connecticut Limited Partnership						Alabama
Select Physical Therapy of Denver, Ltd.						Alabama
Select Physical Therapy of Kendall, Ltd.						Alabama
Select Physical Therapy of St. Louis Limited Partnership						Alabama

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Select Physical Therapy of West Denver Limited Partnership						Alabama
Select Physical Therapy Orthopedic Services, Inc.						Delaware
Select Physical Therapy Texas Limited Partnership						Alabama
Select Rehabilitation Hospital—Hershey, Inc.						Delaware
Select San Diego Physical Therapy, P.C.						California
Select Software Ventures, LLC						Delaware
Select Specialty Hospitals, Inc.						Delaware
Select Specialty Hospital—Akron, LLC						Delaware
Select Specialty Hospital—Ann Arbor, Inc.						Missouri
Select Specialty Hospital—Arizona, Inc.						Delaware
Select Specialty Hospital—Augusta, Inc.						Delaware
Select Specialty Hospital—Beech Grove, Inc.						Missouri
Select Specialty Hospital—Belhaven, LLC						Delaware
Select Specialty Hospital—Boardman, Inc.						Delaware
Select Specialty Hospital—Broward, Inc.						Delaware
Select Specialty Hospital—Central Pennsylvania, L.P.						Delaware
Select Specialty Hospital—Charleston, Inc.						Delaware
Select Specialty Hospital—Cincinnati, Inc.						Missouri
Select Specialty Hospital—Cleveland, LLC						Delaware
Select Specialty Hospital—Colorado Springs, Inc.						Delaware
Select Specialty Hospital—Columbus, Inc.						Delaware
Select Specialty Hospital—Dallas, Inc.						Delaware
Select Specialty Hospital—Danville, Inc.						Delaware
Select Specialty Hospital—Daytona Beach, Inc.						Delaware
Select Specialty Hospital—Denver, Inc.						Delaware
Select Specialty Hospital—Des Moines, Inc.						Delaware
Select Specialty Hospital—Durham, Inc.						Delaware
Select Specialty Hospital—Erie, Inc.						Delaware
Select Specialty Hospital—Evansville, LLC						Delaware
Select Specialty Hospital—Evansville, Inc.						Missouri
Select Specialty Hospital—Flint, Inc.						Missouri
Select Specialty Hospital—Fort Myers, Inc.						Delaware
Select Specialty Hospital—Fort Smith, Inc.						Missouri
Select Specialty Hospital—Gainesville, LLC						Delaware
Select Specialty Hospital—Greensboro, Inc.						Delaware
Select Specialty Hospital—Gulf Coast, Inc.						Missouri
Select Specialty Hospital—Jackson, Inc.						Delaware
Select Specialty Hospital—Johnstown, Inc.						Missouri
Select Specialty Hospital—Kalamazoo, Inc.						Delaware
Select Specialty Hospital—Kansas City, Inc.						Missouri
Select Specialty Hospital—Laurel Highlands, Inc.						Delaware
Select Specialty Hospital—Lexington, Inc.						Delaware
Select Specialty Hospital—Lincoln, Inc.						Delaware
Select Specialty Hospital—Little Rock, Inc.						Delaware
Select Specialty Hospital—Longview, Inc.						Delaware
Select Specialty Hospital—Macomb County, Inc.						Missouri
Select Specialty Hospital—Madison, Inc.						Delaware
Select Specialty Hospital—McKeesport, Inc.						Delaware

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Select Specialty Hospital—Memphis, Inc.						Delaware
Select Specialty Hospital—Miami Lakes, Inc.						Delaware
Select Specialty Hospital—Midtown Atlanta, LLC						Delaware
Select Specialty Hospital—Milwaukee, Inc.						Delaware
Select Specialty Hospital—Nashville, LLC						Delaware
Select Specialty Hospital—North Atlanta, Inc.						Delaware
Select Specialty Hospital—North Knoxville, Inc.						Missouri
Select Specialty Hospital—Northeast New Jersey, Inc.						Delaware
Select Specialty Hospital—Northeast Ohio, Inc.						Missouri
Select Specialty Hospital—Northern Kentucky, LLC						Delaware
Select Specialty Hospital—Oklahoma City, Inc.						Delaware
Select Specialty Hospital—Omaha, Inc.						Missouri
Select Specialty Hospital—Orlando, Inc.						Delaware
Select Specialty Hospital—Palm Beach, Inc.						Delaware
Select Specialty Hospital—Panama City, Inc.						Delaware
Select Specialty Hospital—Pensacola, Inc.						Delaware
Select Specialty Hospital—Phoenix, Inc.						Delaware
Select Specialty Hospital—Pittsburgh/UPMC, Inc.						Delaware
Select Specialty Hospital—Quad Cities, Inc.						Delaware
Select Specialty Hospital—Richmond, Inc.						Delaware
Select Specialty Hospital—Saginaw, Inc.						Delaware
Select Specialty Hospital—San Antonio, Inc.						Delaware
Select Specialty Hospital—Savannah, Inc.						Delaware
Select Specialty Hospital—Sioux Falls, Inc.						Missouri
Select Specialty Hospital—South Dallas, Inc.						Delaware
Select Specialty Hospital—Springfield, Inc.						Delaware
Select Specialty Hospital—Tallahassee, Inc.						Delaware
Select Specialty Hospital—The Villages, Inc.						Delaware
Select Specialty Hospital—TriCities, Inc.						Delaware
Select Specialty Hospital—Tucson, LLC						Delaware
Select Specialty Hospital—Tulsa, Inc.						Delaware
Select Specialty Hospital—Tulsa/Midtown, LLC						Delaware
Select Specialty Hospital—West Tennessee, LLC						Delaware
Select Specialty Hospital—Western Michigan, Inc.						Missouri
Select Specialty Hospital—Wichita, Inc.						Missouri
Select Specialty Hospital—Wilmington, Inc.						Missouri
Select Specialty Hospital—Winston-Salem, Inc.						Delaware
Select Specialty Hospital—Youngstown, Inc.						Missouri
Select Specialty Hospital—Zanesville, Inc.						Delaware
Select Specialty—Downriver, LLC						Delaware
Select Subsidiaries, Inc.						Pennsylvania
Select Synergos, Inc.						Delaware
Select Transport, Inc.						Delaware
Select Tucson Holdings, LLC						Delaware
Select Unit Management, Inc.						Delaware

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SelectMark, Inc.						Delaware
SemperCare, Inc.						Delaware
SLMC Finance Corporation						Delaware
SMCS Holdings, Inc.						Delaware
SMCS Management, LLC						Delaware
SMR Banyan Tree, Inc.						New York
SMR Temple, LLC						Delaware
SMR Tucson, LLC						Delaware
SN Kentuckiana Rehab, LLC						Delaware
Special Care Hospital, LLC						Delaware
Sports Orthopedic Rehabilitation Services, Inc.						Florida
SSM Select Rehab St. Louis, LLC						Delaware
Susquehanna Physical Therapy Associates, Inc.						Pennsylvania
Swanson Orthotic and Prosthetic Center, Inc.						Ohio
The Rehab Center						Pennsylvania
Theraphysics Partners of Colorado, Inc.						Delaware
Theraphysics Partners of Texas, Inc.						Delaware
Therapy Associates of Martinsville, Inc.						Virginia
TheraWorks, Inc.						Texas
TriHealth Rehabilitation, LLC						Delaware
Trumbull P.T. Corp.						Connecticut
VHSD ES, Inc.						Delaware
Vibra Hospital of San Diego, LLC						Delaware
Victoria Healthcare, Inc.						Florida
West Gables Rehabilitation Hospital, LLC						Delaware
Wisconsin Prosthetics & Orthotics, Inc.						Wisconsin
WWLTACH, LLC						Delaware