| | | | | | | | |
| Name of Subsidiary | | Jurisdiction of Organization |
| Penumbra Europe GmbH | | Germany |
| Penumbra Neuro Australia Pty Ltd | | Australia |
| Penumbra Neuro Canada Inc. | | Canada |
| Penumbra Latin America Distribuidora de Equipamentos e Produtos Médicos Ltda. | | Brazil |
| Crossmed S.p.A. | | Italy |
| Penumbra Interventional Therapies UK Ltd. | | United Kingdom |
| Penumbra Singapore Pte. Ltd. | | Singapore |
| Penumbra France SAS | | France |
| Penumbra Japan GK | | Japan |
| Penumbra Israel Ltd | | Israel |
| Penumbra Sweden AB | | Sweden |
| Penumbra Denmark ApS | | Denmark |
| Xtract Medical, Inc. | | Delaware |
| Penumbra Marketing MEA FZE | | United Arab Emirates |
| Penumbra Poland sp. z o.o. | | Poland |
| Penumbra Costa Rica, S.R.L. | | Costa Rica |