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Exhibit 21

SIGNIFICANT SUBSIDIARIES

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List of Subsidiaries 

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Jurisdiction of Incorporation or Organization 

Altimmune, LLC (1)

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Delaware

Altimmune UK, Limited (1)

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United Kingdom

Spitfire Pharma, LLC (1)

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Delaware

Altimmune AU Pty, Limited (1)

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Australia

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(1)

Wholly owned subsidiary of the Company