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Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the following Registration Statements:

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(1)

Registration Statement (Form S-8 No. 333-278273) pertaining to 2017 Omnibus Incentive Plan of Altimmune, Inc.,

(2)

Registration Statement (Form S-8 No. 333-270109) pertaining to 2017 Omnibus Incentive Plan of Altimmune, Inc.,

(3)

Registration Statement (Form S-8 No. 333-263569) pertaining to 2017 Omnibus Incentive Plan of Altimmune, Inc.,

(4)

Registration Statement (Form S-8 No. 333-248232) pertaining to 2017 Omnibus Incentive Plan of Altimmune, Inc.,

(5)

Registration Statement (Form S-8 No. 333-233273) pertaining to 2017 Omnibus Incentive Plan of Altimmune, Inc.,

(6)

Registration Statement (Form S-8 No. 333-230722) pertaining to 2019 Employee Stock Purchase Plan of Altimmune, Inc.,

(7)

Registration Statement (Form S-8 No. 333-228623) pertaining to 2018 Inducement Grant Plan of Altimmune Inc.,

(8)

Registration Statement (Form S-8 No. 333-217846) pertaining to 2001 Employee Stock Option Plan, 2001 Non-Employee Stock Option Plan, and 2017 Omnibus Incentive Plan of Altimmune, Inc.,

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of our report dated February 27, 2025, with respect to the consolidated financial statements of Altimmune, Inc., included in this Annual Report (Form 10-K) of Altimmune, Inc. for the year ended December 31, 2024.

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/s/ Ernst & Young LLP

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Iselin, New Jersey

February 27, 2025

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