![[MISSING IMAGE: sg_jackakhattarnew1-bw.jpg]](sg_jackakhattarnew1-bw.jpg) 
        | 
                Name and Address of Beneficial Owner 
               |  |  | 
                Number of Shares 
                 of Common Stock Beneficially Owned |  |  | 
                Percentage of Shares 
                 of Common Stock Beneficially Owned |  | ||||||
| 5% Stockholders: |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                BlackRock, Inc. and its affiliates(1)
                 55 East 52nd Street New York, NY 10055 |  |  |  |  | 8,451,022 |  |  |  |  |  | 15.8% |  |  | 
| 
                The Vanguard Group and its affiliates(2) 
                 100 Vanguard Blvd. Malvern, PA 19355 |  |  |  |  | 5,513,149 |  |  |  |  |  | 10.3% |  |  | 
| 
                Armistice Capital, LLC(3) 
                 510 Madison Avenue, 7th Floor New York, NY 10022 |  |  |  |  | 4,136,000 |  |  |  |  |  | 7.7% |  |  | 
| Executive Officers and Directors: |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                Jack A. Khattar+(4)
               |  |  |  |  | 3,712,541 |  |  |  |  |  | 6.7% |  |  | 
| 
                James P. Kelly+
               |  |  |  |  | — |  |  |  |  |  | * |  |  | 
| 
                Timothy C. Dec+
               |  |  |  |  | — |  |  |  |  |  | * |  |  | 
| 
                Padmanabh P. Bhatt, Ph.D.+(5)
               |  |  |  |  | 181,394 |  |  |  |  |  | * |  |  | 
| 
                Jonathan Rubin, M.D.+(6)
               |  |  |  |  | 13,750 |  |  |  |  |  | * |  |  | 
| 
                Tami T. Martin, R.N., Esq.+(7)
               |  |  |  |  | 192,220 |  |  |  |  |  | * |  |  | 
| 
                Frank Mottola(8)
               |  |  |  |  | 89,194 |  |  |  |  |  | * |  |  | 
| 
                Carrolee Barlow, M.D., Ph.D.(9)
               |  |  |  |  | 46,190 |  |  |  |  |  | * |  |  | 
| 
                Georges Gemayel, Ph.D.(10)
               |  |  |  |  | 111,084 |  |  |  |  |  | * |  |  | 
| 
                Frederick M. Hudson(11)
               |  |  |  |  | 125,093 |  |  |  |  |  | * |  |  | 
| 
                Charles W. Newhall, III(12)
               |  |  |  |  | 202,358 |  |  |  |  |  | * |  |  | 
| 
                John M. Siebert, Ph.D.(13)
               |  |  |  |  | 131,826 |  |  |  |  |  | * |  |  | 
| 
                All executive officers and directors as a group (12 persons) 
               |  |  |  |  | 4,802,650 |  |  |  |  |  | 8.7% |  |  | 
| 
                Name 
               |  |  | 
                Age 
               |  |  | 
                Director 
                 Since |  |  | 
                Position 
               |  | ||||||
| Class I Directors (Term maturing in 2022) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                Carrolee Barlow, M.D., Ph.D. 
               |  |  |  |  | 58 |  |  |  |  |  | 2018 |  |  |  | Director |  | 
| 
                Jack A. Khattar 
               |  |  |  |  | 60 |  |  |  |  |  | 2005 |  |  |  | 
                President, Chief Executive Officer
               
                and Secretary, Director 
               |  | 
| Class II Directors (Term maturing in 2023): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                Frederick M. Hudson(1)(2)
               |  |  |  |  | 76 |  |  |  |  |  | 2010 |  |  |  | Director |  | 
| 
                Charles W. Newhall, III(2)(3)
               |  |  |  |  | 77 |  |  |  |  |  | 2005 |  |  |  | Director |  | 
| Class III Directors (Term maturing in 2024): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                Georges Gemayel, Ph.D.(1)(3)
               |  |  |  |  | 62 |  |  |  |  |  | 2015 |  |  |  | Director |  | 
| 
                John M. Siebert, Ph.D.(1)(2)
               |  |  |  |  | 82 |  |  |  |  |  | 2011 |  |  |  | Director |  | 
|  |  |  | 
                Female 
               |  |  | 
                Male 
               |  |  | 
                Non-Binary 
               |  |  | 
                Did Not Disclose 
                 Gender |  | ||||||||||||
| 
                Gender Identity 
               |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                Directors 
               |  |  |  |  | 1 |  |  |  |  |  | 5 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  | 
| Demographic Background |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                African American or Black 
               |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  | 
| 
                Alaskan Native or Native American 
               |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  | 
| 
                Asian 
               |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  | 
| 
                Hispanic or Latinx 
               |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  | 
| 
                Native Hawaiian or Pacific Islander 
               |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  | 
| 
                Two or More Races or Ethnicities 
               |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  | 
| White(1)(2) |  |  |  |  | 1 |  |  |  |  |  | 5 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  | 
| 
                LGBTQ+ 
               |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  | 
| 
                Did not Disclose Demographic Background 
               |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  |  |  |  | 0 |  |  | 
| 
                Name 
               |  |  | 
                Age 
               |  |  | 
                Position(s) 
               |  | |||
| 
                Jack A. Khattar 
               |  |  |  |  | 60 |  |  |  | 
                President, Chief Executive Officer & Secretary, Director 
               |  | 
| 
                Timothy C. Dec 
               |  |  |  |  | 64 |  |  |  | Senior Vice President, Chief Financial Officer |  | 
| 
                Padmanabh P. Bhatt, Ph.D. 
               |  |  |  |  | 64 |  |  |  | Senior Vice President Intellectual Property, Chief Scientific Officer |  | 
| 
                Tami T. Martin, R.N., Esq. 
               |  |  |  |  | 66 |  |  |  | Senior Vice President, Regulatory Affairs |  | 
| 
                Frank Mottola 
               |  |  |  |  | 50 |  |  |  | Senior Vice President, Quality, GMP Operations and Information Technology |  | 
| 
                Jonathan Rubin, M.D. 
               |  |  |  |  | 60 |  |  |  | Senior Vice President, Chief Medical Officer, Research and Development |  | 
| 
                Name 
               |  |  | 
                Target Bonus
                 as a % of Base Salary) |  |  | 
                Weighting of
                 Objectives |  | ||||||||||||
|  | 
                Company 
               |  |  | 
                Individual 
               |  | ||||||||||||||
| 
                Jack A. Khattar 
               |  |  |  |  | 75% |  |  |  |  |  | 100% |  |  |  |  |  | 0%(1) |  |  | 
| 
                Timothy C. Dec 
               |  |  |  |  | 40% |  |  |  |  |  | 60% |  |  |  |  |  | 40% |  |  | 
| 
                Padmanabh P. Bhatt, Ph.D. 
               |  |  |  |  | 35% |  |  |  |  |  | 60% |  |  |  |  |  | 40% |  |  | 
| 
                Jonathan Rubin, M.D., 
               |  |  |  |  | 35% |  |  |  |  |  | 60% |  |  |  |  |  | 40% |  |  | 
| 
                Tami T. Martin, R.N., Esq. 
               |  |  |  |  | 35% |  |  |  |  |  | 60% |  |  |  |  |  | 40% |  |  | 
| 
                James P. Kelly(2)
               |  |  |  |  | 45% |  |  |  |  |  | 60% |  |  |  |  |  | 40% |  |  | 
| 
                Name and Principal Position 
               |  |  | 
                Year 
               |  |  | 
                Salary ($) 
               |  |  | 
                Stock 
                 Awards ($)(1) |  |  | 
                Option 
                 Awards ($)(2) |  |  | 
                Non-Equity 
                 Incentive Plan Compensation ($)(3) |  |  | 
                All Other 
                 Compensation ($)(4) |  |  | 
                Total ($) 
               |  | |||||||||||||||||||||
| 
                Jack A. Khattar 
                 Chief Executive Officer, President & Secretary |  |  |  |  | 2021 |  |  |  |  |  | 870,000 |  |  |  |  |  | 2,941,400 |  |  |  |  |  | 3,399,779 |  |  |  |  |  | 887,400 |  |  |  |  |  | 18,142 |  |  |  |  |  | 8,116,721 |  |  | 
|  |  |  | 2020 |  |  |  |  |  | 836,400 |  |  |  |  |  | 1,032,813 |  |  |  |  |  | 3,955,883 |  |  |  |  |  | 815,500 |  |  |  |  |  | 28,451 |  |  |  |  |  | 6,669,046 |  |  | ||
|  |  |  | 2019 |  |  |  |  |  | 812,000 |  |  |  |  |  | — |  |  |  |  |  | 6,637,646 |  |  |  |  |  | 593,800 |  |  |  |  |  | 79,686 |  |  |  |  |  | 8,123,132 |  |  | ||
| 
                Timothy C. Dec(5) 
                 Senior Vice President, Chief Financial Officer |  |  |  |  | 2021 |  |  |  |  |  | 135,096 |  |  |  |  |  | — |  |  |  |  |  | 1,238,685 |  |  |  |  |  | 72,300 |  |  |  |  |  | 7,454 |  |  |  |  |  | 1,453,535 |  |  | 
| 
                Jonathan Rubin, MD(6) 
                 Senior Vice President, Chief Medical Officer Research and Development |  |  |  |  | 2021 |  |  |  |  |  | 385,000 |  |  |  |  |  | 45,675 |  |  |  |  |  | 424,972 |  |  |  |  |  | 143,700 |  |  |  |  |  | 29,002 |  |  |  |  |  | 1,028,349 |  |  | 
| 
                Padmanabh P. Bhatt, Ph.D. 
                 Senior Vice President, Intellectual Property, Chief Scientific Officer |  |  |  |  | 2021 |  |  |  |  |  | 403,100 |  |  |  |  |  | 45,675 |  |  |  |  |  | 288,981 |  |  |  |  |  | 158,900 |  |  |  |  |  | 36,608 |  |  |  |  |  | 933,265 |  |  | 
|  |  |  | 2020 |  |  |  |  |  | 391,401 |  |  |  |  |  | — |  |  |  |  |  | 492,288 |  |  |  |  |  | 161,600 |  |  |  |  |  | 29,201 |  |  |  |  |  | 1,074,490 |  |  | ||
|  |  |  | 2019 |  |  |  |  |  | 380,018 |  |  |  |  |  | — |  |  |  |  |  | 774,392 |  |  |  |  |  | 131,000 |  |  |  |  |  | 26,177 |  |  |  |  |  | 1,311,587 |  |  | ||
| 
                Tami Martin, R.N., Esq. 
                 Senior Vice President, Regulatory Affairs |  |  |  |  | 2021 |  |  |  |  |  | 336,200 |  |  |  |  |  | 45,675 |  |  |  |  |  | 288,981 |  |  |  |  |  | 129,700 |  |  |  |  |  | 42,601 |  |  |  |  |  | 843,157 |  |  | 
|  |  |  | 2020 |  |  |  |  |  | 326,401 |  |  |  |  |  | — |  |  |  |  |  | 309,438 |  |  |  |  |  | 131,200 |  |  |  |  |  | 37,598 |  |  |  |  |  | 804,637 |  |  | ||
|  |  |  | 2019 |  |  |  |  |  | 316,891 |  |  |  |  |  | — |  |  |  |  |  | 424,540 |  |  |  |  |  | 91,400 |  |  |  |  |  | 41,988 |  |  |  |  |  | 874,819 |  |  | ||
| 
                James P. Kelly(7) 
                 Former Executive Vice President, Chief Financial Officer |  |  |  |  | 2021 |  |  |  |  |  | 292,188 |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | 43,874 |  |  |  |  |  | 636,720 |  |  | 
|  |  |  | 2020 |  |  |  |  |  | 102,910 |  |  |  |  |  | — |  |  |  |  |  | 1,641,727 |  |  |  |  |  | 50,900 |  |  |  |  |  | 6,099 |  |  |  |  |  | 1,801,636 |  |  | ||
|  |  |  |  |  |  |  |  |  | 
                Estimated Future 
                 Payouts Under Non-Equity Incentive Plan Awards |  |  | 
                Estimated Future 
                 Payouts Under Equity Incentive Plan Awards |  |  | 
                Exercise 
                 or Base Price of Option Awards ($/Sh)(2) |  |  | 
                Grant 
                 Date Fair Value of Stock and Option Awards ($)(3) |  | ||||||||||||||||||||||||||||||||||||
| 
                Name 
               |  |  | 
                Grant Date 
               |  |  | 
                Threshold 
                 ($) |  |  | 
                Target 
                 ($)(1) |  |  | 
                Maximum 
                 ($) |  |  | 
                Threshold 
                 (#) |  |  | 
                Target 
                 (#) |  |  | 
                Maximum 
                 (#) |  | |||||||||||||||||||||||||||||||||
| 
                Jack A. Khattar 
               |  |  |  |  | 2/19/2021 |  |  |  |  |  | — |  |  |  |  |  | 652,500 |  |  |  |  |  | 652,500 |  |  |  |  |  | — |  |  |  |  |  | 200,000 |  |  |  |  |  | 200,000 |  |  |  |  |  | 17.00 |  |  |  |  |  | 3,399,779 |  |  | 
|  |  |  | 2/19/2021 |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | 20,000 |  |  |  |  |  | 20,000 |  |  |  |  |  |  |  |  |  |  |  | 572,600 |  |  | ||
|  |  |  | 2/19/2021 |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | 80,000 |  |  |  |  |  | 80,000 |  |  |  |  |  |  |  |  |  |  |  | 2,368,800 |  |  | ||
| 
                Timothy C. Dec 
               |  |  |  |  | 8/23/2021 |  |  |  |  |  | — |  |  |  |  |  | 150,000 |  |  |  |  |  | 150,000 |  |  |  |  |  | — |  |  |  |  |  | 85,000 |  |  |  |  |  | 85,000 |  |  |  |  |  | 14.57 |  |  |  |  |  | 1,238,685 |  |  | 
| 
                Jonathan Rubin, MD 
               |  |  |  |  | 2/19/2021 |  |  |  |  |  | — |  |  |  |  |  | 134,750 |  |  |  |  |  | 134,750 |  |  |  |  |  | — |  |  |  |  |  | 25,000 |  |  |  |  |  | 25,000 |  |  |  |  |  | 17.00 |  |  |  |  |  | 424,972 |  |  | 
|  |  |  | 4/30/2021(4) |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | 1,500 |  |  |  |  |  | 1,500 |  |  |  |  |  |  |  |  |  |  |  | 45,675 |  |  | ||
| 
                Padmanabh P. Bhatt, Ph.D. 
               |  |  |  |  | 2/19/2021 |  |  |  |  |  | — |  |  |  |  |  | 141,085 |  |  |  |  |  | 141,085 |  |  |  |  |  | — |  |  |  |  |  | 17,000 |  |  |  |  |  | 17,000 |  |  |  |  |  | 17.00 |  |  |  |  |  | 288,981 |  |  | 
|  |  |  | 4/30/2021(4) |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | 750 |  |  |  |  |  | 750 |  |  |  |  |  |  |  |  |  |  |  | 22,838 |  |  | ||
|  |  |  | 4/30/2021(4) |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | 750 |  |  |  |  |  | 750 |  |  |  |  |  |  |  |  |  |  |  | 22,838 |  |  | ||
| 
                Tami Martini, R.N., Esq. 
               |  |  |  |  | 2/19/2021 |  |  |  |  |  | — |  |  |  |  |  | 117,670 |  |  |  |  |  | 117,670 |  |  |  |  |  | — |  |  |  |  |  | 17,000 |  |  |  |  |  | 17,000 |  |  |  |  |  | 17.00 |  |  |  |  |  | 288,981 |  |  | 
|  |  |  | 4/30/2021(4) |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | 1,500 |  |  |  |  |  | 1,500 |  |  |  |  |  |  |  |  |  |  |  | 45,675 |  |  | ||
| 
                James P. Kelly 
               |  |  |  |  | 2/19/2021 |  |  |  |  |  |  |  |  |  |  |  | 210,375 |  |  |  |  |  | 210,375 |  |  |  |  |  |  |  |  |  |  |  | 15,000 |  |  |  |  |  | 15,000 |  |  |  |  |  | 17.00 |  |  |  |  |  | 254,983 |  |  | 
|  |  |  | 4/30/2021(4) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500 |  |  |  |  |  | 1,500 |  |  |  |  |  |  |  |  |  |  |  | 45,675 |  |  | ||
|  |  |  | 
                Options Awards(1)
               |  |  | 
                Stock Awards(2)
               |  | ||||||||||||||||||||||||||||||
| 
                Name 
               |  |  | 
                Number of 
                 Securities Underlying Unexercised Options (#) Exercisable |  |  | 
                Number of 
                 Securities Underlying Unexercised Options (#) Unexercisable |  |  | 
                Option 
                 Exercise Price ($)(3) |  |  | 
                Option 
                 Expiration Date |  |  | 
                Number of 
                 Shares or Units of Stock That Have Not Vested |  |  | 
                Market 
                 Value of Shares or Units of Stock That Have Not Vested ($)(4) |  | ||||||||||||||||||
| 
                Jack A. Khattar 
               |  |  |  |  | — |  |  |  |  |  | 200,000 |  |  |  |  |  | 29.61 |  |  |  |  |  | 2/19/2031 |  |  |  |  |  | 75,625 |  |  |  |  |  | 2,205,225 |  |  | 
|  |  |  | 70,313 |  |  |  |  |  | 210,937 |  |  |  |  |  | 23.99 |  |  |  |  |  | 2/21/2030 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 150,000 |  |  |  |  |  | 150,000 |  |  |  |  |  | 36.75 |  |  |  |  |  | 2/22/2029 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 187,500 |  |  |  |  |  | 62,500 |  |  |  |  |  | 39.40 |  |  |  |  |  | 2/14/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 325,000 |  |  |  |  |  | 0 |  |  |  |  |  | 25.30 |  |  |  |  |  | 2/24/2027 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 255,000 |  |  |  |  |  | — |  |  |  |  |  | 12.98 |  |  |  |  |  | 3/1/2026 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 250,000 |  |  |  |  |  | — |  |  |  |  |  | 9.13 |  |  |  |  |  | 3/3/2025 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 150,000 |  |  |  |  |  | — |  |  |  |  |  | 9.56 |  |  |  |  |  | 1/23/2024 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 392,000 |  |  |  |  |  | — |  |  |  |  |  | 7.90 |  |  |  |  |  | 2/5/2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
| 
                Timothy C. Dec 
               |  |  |  |  | — |  |  |  |  |  | 85,000 |  |  |  |  |  | 25.09 |  |  |  |  |  | 8/23/2031 |  |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Jonathan Rubin, MD 
               |  |  |  |  | — |  |  |  |  |  | 25,000 |  |  |  |  |  | 29.61 |  |  |  |  |  | 2/19/2031 |  |  |  |  |  | 1,500 |  |  |  |  |  | 43,740 |  |  | 
|  |  |  | 3,750 |  |  |  |  |  | 11,250 |  |  |  |  |  | 23.99 |  |  |  |  |  | 2/21/2030 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
| 
                Padmanabh P. Bhatt, Ph.D. 
               |  |  |  |  | — |  |  |  |  |  | 17,000 |  |  |  |  |  | 29.61 |  |  |  |  |  | 2/19/2031 |  |  |  |  |  | 1,500 |  |  |  |  |  | 43,740 |  |  | 
|  |  |  | 8,750 |  |  |  |  |  | 26,250 |  |  |  |  |  | 23.99 |  |  |  |  |  | 2/21/2030 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 17,500 |  |  |  |  |  | 17,500 |  |  |  |  |  | 36.75 |  |  |  |  |  | 2/22/2029 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 22,500 |  |  |  |  |  | 7,500 |  |  |  |  |  | 39.40 |  |  |  |  |  | 2/14/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 40,000 |  |  |  |  |  | — |  |  |  |  |  | 25.30 |  |  |  |  |  | 2/24/2027 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 40,000 |  |  |  |  |  | — |  |  |  |  |  | 12.98 |  |  |  |  |  | 3/1/2026 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 15,000 |  |  |  |  |  | — |  |  |  |  |  | 9.13 |  |  |  |  |  | 3/3/2025 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 7,500 |  |  |  |  |  | — |  |  |  |  |  | 9.24 |  |  |  |  |  | 1/21/2024 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
| 
                Tami Martin, R.N., Esq 
               |  |  |  |  | — |  |  |  |  |  | 17,000 |  |  |  |  |  | 29.61 |  |  |  |  |  | 2/19/2031 |  |  |  |  |  | 1,500 |  |  |  |  |  | 43,740 |  |  | 
|  |  |  | 5,500 |  |  |  |  |  | 16,500 |  |  |  |  |  | 23.99 |  |  |  |  |  | 2/21/2030 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 10,000 |  |  |  |  |  | 10,000 |  |  |  |  |  | 36.75 |  |  |  |  |  | 2/22/2029 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 9,000 |  |  |  |  |  | 3,000 |  |  |  |  |  | 39.40 |  |  |  |  |  | 2/14/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 13,500 |  |  |  |  |  | — |  |  |  |  |  | 25.30 |  |  |  |  |  | 2/24/2027 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 6,250 |  |  |  |  |  | — |  |  |  |  |  | 12.98 |  |  |  |  |  | 3/1/2026 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 25,000 |  |  |  |  |  | — |  |  |  |  |  | 9.13 |  |  |  |  |  | 3/3/2025 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 8,000 |  |  |  |  |  | — |  |  |  |  |  | 9.24 |  |  |  |  |  | 1/24/2024 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
|  |  |  | 10,000 |  |  |  |  |  |  |  |  |  |  |  | 7.90 |  |  |  |  |  | 2/5/2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ||
| 
                James P. Kelly(5)
               |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  | 
|  |  |  | 
                Option Awards 
               |  |  | 
                Stock Awards 
               |  | ||||||||||||||||||
| 
                Name 
               |  |  | 
                Number of Shares
                 Acquired On Exercise (#) |  |  | 
                Value
                 Realized On Exercise ($) |  |  | 
                Number of Shares
                 Acquired On Vesting (#) |  |  | 
                Value
                 Realized On Vesting ($) |  | ||||||||||||
| 
                Jack A. Khattar 
               |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | 40,000 |  |  |  |  |  | 1,053,200 |  |  | 
| 
                Timothy C. Dec 
               |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Jonathan Rubin, MD 
               |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Padmanabh P. Bhatt, Ph.D. 
               |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Tami Martin, R.N., Esq. 
               |  |  |  |  | 6,250 |  |  |  |  |  | 112,515 |  |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                James P. Kelly 
               |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Name 
               |  |  | 
                Benefit 
               |  |  | 
                Termination 
                 Upon a Restructuring |  |  | 
                Termination 
                 Without Cause or Resignation for Good Reason |  |  | 
                Resignation 
                 for Good Reason After a Change of Control |  | |||||||||
| 
                Jack A. Khattar 
               |  |  | 
                Base salary continuation 
               |  |  |  | $ | 1,305,000 |  |  |  |  | $ | 1,305,000 |  |  |  |  | $ | 1,305,000 |  |  | 
|  | Bonus(1) |  |  |  | $ | 815,500 |  |  |  |  | $ | 815,500 |  |  |  |  | $ | 815,500 |  |  | ||
|  | Continuation of benefits(2) |  |  |  | $ | 29,302 |  |  |  |  | $ | 29,302 |  |  |  |  | $ | 29,302 |  |  | ||
|  | Total |  |  |  |  |  |  |  |  |  | $ | 2,149,802 |  |  |  |  | $ | 2,149,802 |  |  | ||
| 
                Timothy C. Dec 
               |  |  | 
                Base salary continuation 
               |  |  |  | $ | 375,000 |  |  |  |  | $ | 375,000 |  |  |  |  | $ | 375,000 |  |  | 
|  | Bonus(3) |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  | ||
|  | Continuation of benefits(4) |  |  |  | $ | 23,659 |  |  |  |  | $ | 23,659 |  |  |  |  | $ | 23,659 |  |  | ||
|  | Total |  |  |  |  |  |  |  |  |  | $ | 398,659 |  |  |  |  | $ | 398,659 |  |  | ||
| 
                Jonathan Rubin, MD 
               |  |  | 
                Base salary continuation 
               |  |  |  | $ | 385,000 |  |  |  |  | $ | 385,000 |  |  |  |  | $ | 385,000 |  |  | 
|  | Bonus(3) |  |  |  | $ | 110,500 |  |  |  |  | $ | 110,500 |  |  |  |  | $ | 110,500 |  |  | ||
|  | Continuation of benefits(4) |  |  |  | $ | 19,534 |  |  |  |  | $ | 19,534 |  |  |  |  | $ | 19,534 |  |  | ||
|  | Total |  |  |  |  |  |  |  |  |  | $ | 515,035 |  |  |  |  | $ | 515,035 |  |  | ||
| 
                Padmanabh P. Bhatt, Ph.D. 
               |  |  | Severance |  |  |  | $ | 201,550 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 
                Tami Martin, R.N., Esq 
               |  |  | 
                Base salary continuation 
               |  |  |  | $ | 336,200 |  |  |  |  | $ | 336,200 |  |  |  |  | $ | 336,200 |  |  | 
|  | Bonus(3) |  |  |  | $ | 131,200 |  |  |  |  | $ | 131,200 |  |  |  |  | $ | 131,200 |  |  | ||
|  | Continuation of benefits(4) |  |  |  | $ | 19,534 |  |  |  |  | $ | 19,534 |  |  |  |  | $ | 19,534 |  |  | ||
|  | Total |  |  |  |  |  |  |  |  |  | $ | 486,935 |  |  |  |  | $ | 486,935 |  |  | ||
| 
                James P. Kelly(5)
               |  |  | Total |  |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Committee 
               |  |  | 
                Chairman
                 ($) |  |  | 
                Member
                 ($) |  | ||||||
| 
                Audit Committee 
               |  |  |  |  | 25,000 |  |  |  |  |  | 12,500 |  |  | 
| 
                Compensation Committee 
               |  |  |  |  | 20,000 |  |  |  |  |  | 10,000 |  |  | 
| 
                Governance and Nominating Committee 
               |  |  |  |  | 11,000 |  |  |  |  |  | 5,000 |  |  | 
| 
                Name 
               |  |  | 
                Fees Earned 
                 or Paid in Cash ($) |  |  | 
                Stock 
                 Awards ($)(1) |  |  | 
                Option 
                 Awards ($)(1) |  |  | 
                Total 
                 ($) |  | ||||||||||||
| 
                Georges Gemayel 
               |  |  |  |  | 67,500(2) |  |  |  |  |  | 125,013 |  |  |  |  |  | 125,197 |  |  |  |  |  | 317,710 |  |  | 
| 
                Frederick M. Hudson 
               |  |  |  |  | 85,000(3) |  |  |  |  |  | 125,013 |  |  |  |  |  | 125,197 |  |  |  |  |  | 335,210 |  |  | 
| 
                Charles W. Newhall, III 
               |  |  |  |  | 101,000(4) |  |  |  |  |  | 125,013 |  |  |  |  |  | 125,197 |  |  |  |  |  | 351,210 |  |  | 
| 
                John M. Siebert, Ph.D. 
               |  |  |  |  | 82,500(5) |  |  |  |  |  | 125,013 |  |  |  |  |  | 125,197 |  |  |  |  |  | 332,710 |  |  | 
| 
                Carrolee Barlow, M.D., Ph.D. 
               |  |  |  |  | 50,000(6) |  |  |  |  |  | 125,013 |  |  |  |  |  | 125,197 |  |  |  |  |  | 300,210 |  |  | 
|  |  |  | 
                2021 
               |  |  | 
                2020 
               |  | ||||||
| 
                Audit fees 
               |  |  |  | $ | 2,110 |  |  |  |  | $ | 2,400 |  |  | 
| 
                Audit-related fees 
               |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Tax fees 
               |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                All other fees 
               |  |  |  |  | — |  |  |  |  |  | — |  |  | 
| 
                Total 
               |  |  |  | $ | 2,110 |  |  |  |  | $ | 2,400 |  |  | 
![[MISSING IMAGE: tm223570d1-px_superpg14c.jpg]](tm223570d1-px_superpg14c.jpg) 
        ![[MISSING IMAGE: tm223570d1-px_superpg24c.jpg]](tm223570d1-px_superpg24c.jpg)