| Name of Subsidiaries | Jurisdiction of Organization | ||||
| Sage Therapeutics, LLC | Delaware | ||||
| Sage Securities Corporation | Massachusetts | ||||
| MDD US Enterprises, LLC | Delaware | ||||
| MDD US Operations, LLC | Delaware | ||||
| Adamas Pharmaceuticals, LLC | Delaware | ||||
| Adamas Operations, LLC | Delaware | ||||
| Adamas Holdings, LLC | Delaware | ||||
| Biscayne Neurotherapeutics, Inc. | Delaware | ||||