November 18, 2013
United States Securities and Exchange Commission
 Division of Corporation Finance
 100 F Street, N.E.
 Washington, DC 20549
Attention: Jeffrey P. Riedler, Assistant Director
Bryan J. Pitko, Attorney-Advisor
Christina De Rosa, Attorney-Advisor
Scott Wuenschell, Staff Accountant
Joel Parker, Staff Accountant
Re: TetraLogic Pharmaceuticals Corporation
Registration Statement on Form S-1 (File No. 333-191811)
Ladies and Gentlemen:
In connection with the above-captioned Registration Statement, we wish to advise that between November 6, 2013 and the date hereof, 2,320 copies of the Preliminary Prospectus dated November 6, 2013 were distributed to prospective underwriters, institutional investors and prospective dealers.
We have been informed by the participating underwriters that they will comply with the requirements of Rule 15c2-8 under the Securities Exchange Act of 1934, as amended.
We hereby join in the request of the registrant that the effectiveness of the above-captioned Registration Statement, as amended, be accelerated to 4:00 p.m. Eastern Standard Time, on Wednesday, November 20, 2013 or as soon thereafter as practicable.
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| Very truly yours, | 
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| OPPENHEIMER & CO. INC. | 
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| GUGGENHEIM SECURITIES, LLC | 
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| NEEDHAM & COMPANY, LLC | 
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| As representatives of the | 
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| Prospective Underwriters | 
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| By: | Oppenheimer & Co. Inc. | ||
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| By: | /s/ Arun Master | 
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 | Name: | Arun Master | |
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 | Title: | Executive Director | |
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| By: | Guggenheim Securities, LLC | ||
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| By: | /s/ Paul M. Friedman | 
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 | Name: | Paul M. Friedman | |
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 | Title: | Senior Managing Director | |
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 | Chief Operating Officer | |
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| By: | Needham & Company, LLC | ||
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| By: | /s/ Charles V. Baltic | 
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 | Name: | Charles V. Baltic | |
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 | Title: | Managing Director | |