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Exhibit 107

Calculation of Filing Fee Table

FORM 424B2

TAKEDA YAKUHIN KOGYO KABUSHIKI KAISHA

(Exact Name of Registrant as Specified in Its Charter)

TAKEDA PHARMACEUTICAL COMPANY LIMITED

(Translation of registrant’s name into English)

Table 1: Newly Registered Securities

Security Type

Security Class Title

Fee Calculation or Carry Forward Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Fees to Be Paid

Debt

$1,100,000,000 5.300% Senior Notes due 2034

457(r)

$1,100,000,000

99.724%

$1,096,964,000

0.0001476

$161,911.89

Fees to Be Paid

Debt

$800,000,000 5.650% Senior Notes due 2044

457(r)

$800,000,000

99.561%

$796,488,000

0.0001476

$117,561.63

Fees to Be Paid

Debt

$600,000,000 5.650% Senior Notes due 2054

457(r)

$600,000,000

99.570%

$597,420,000

0.0001476

$88,179.19

Fees to Be Paid

Debt

$500,000,000 5.800% Senior Notes due 2064

457(r)

$500,000,000

99.537%

$497,685,000

0.0001476

$73,458.31

Fees Previously Paid

N/A

N/A

N/A

N/A

N/A

N/A

N/A

Total Offering Amounts

$2,988,557,000

$441,111.01

Total Fees Previously Paid

N/A

Total Fee Offsets

N/A

Net Fee Due

$441,111.01