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Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Checkbox not checked   Rule 13d-1(b)
Checkbox checked   Rule 13d-1(c)
Checkbox not checked   Rule 13d-1(d)






SCHEDULE 13G




Comment for Type of Reporting Person:  (1) Takeda Pharmaceutical Company Limited's ("Takeda") beneficial ownership of the issuer's common stock ("Common Stock") is comprised of 1,781,996 shares of Common Stock that it holds directly and 7,000,000 shares of Common Stock held by Takeda Pharmaceuticals U.S.A., Inc. ("TPUSA"). TPUSA is owned directly by Takeda Pharmaceuticals International AG. Takeda Pharmaceuticals International AG is a wholly owned subsidiary of Takeda. As such, Takeda may be deemed to have indirect beneficial ownership of the securities held by TPUSA. (2) Based on 71,212,353 shares of Common Stock issued and outstanding as of November 7, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q, filed with the Securities and Exchange Commission on November 12, 2025.


SCHEDULE 13G




Comment for Type of Reporting Person:  (1) Takeda shares beneficial ownership of 7,000,000 shares of Common Stock held by TPUSA. TPUSA is owned directly by Takeda Pharmaceuticals International AG. Takeda Pharmaceuticals International AG is a wholly owned subsidiary of Takeda. (2) Based on 71,212,353 shares of Common Stock issued and outstanding as of November 7, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q, filed with the Securities and Exchange Commission on November 12, 2025.


SCHEDULE 13G



 
Takeda Pharmaceutical Company Limited
 
Signature:/s/ Max Heuer
Name/Title:Max Heuer / Authorized Signatory
Date:12/09/2025
 
Takeda Pharmaceutical U.S.A., Inc.
 
Signature:/s/ Paul Sundberg
Name/Title:Paul Sundberg / Assistant Secretary
Date:12/09/2025
Exhibit Information

Exhibit 99.1 Identification of the subsidiary which acquired the security being reported on by the parent holding company Exhibit 99.2 Joint Filing Agreement