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Exhibit 8.1

Subsidiaries of the Registrant

Subsidiaries of Registrant

  ​ ​ ​

Jurisdiction of
Incorporation

  ​ ​ ​

2025 Company
voting rights
(%)

Aptuit Global LLC, Princeton, US

Delaware

100.00

Aptuit (Verona) SRL, Verona, Italy

Italy

100.00

Aptuit (Oxford) Ltd., Abingdon, UK

England

100.00

Cyprotex Discovery Ltd., Manchester, UK

England

100.00

Cyprotex Ltd., Manchester, UK

England

100.00

Cyprotex US, LLC., Framingham, US

Delaware

100.00

Evotec Asia Pte. Ltd., Singapore*

Singapore

100.00

Evotec (France) SAS, Toulouse, France

France

100.00

Evotec ID (Lyon) SAS, Lyon, France

France

100.00

Evotec (Hamburg) GmbH, Hamburg, Germany

Germany

100.00

Evotec GT GmbH, Vienna, Austria*

Austria

100.00

Evotec (India) Private Ltd., Thane, India*

India

100.00

Evotec International GmbH, Hamburg, Germany

Germany

100.00

Evotec (Modena) Srl, Medolla, Italy

Italy

100,00

Evotec (UK) Ltd., Abingdon, UK

England

100.00

Evotec (US) Inc., Princeton, NJ, US

Delaware

100.00

Just-Evotec Biologics, Inc., Seattle, US

Delaware

100.00

NephThera GmbH, Hamburg, Germany

Germany

100.00

*In liquidation