<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001535610-24-000024</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001535610</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>1</amendmentNo>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>12/31/2024</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001430306</issuerCik>
        <issuerName>Tonix Pharmaceuticals Holding Corp.</issuerName>
        <issuerCusip>890260854</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>26 MAIN STREET, SUITE 101</com:street1>
          <com:street2>26 MAIN STREET, SUITE 101</com:street2>
          <com:city>CHATHAM</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07928</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>SABBY MANAGEMENT, LLC</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>1306313.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>1306313.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1306313.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>0.7</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>SABBY VOLATILITY WARRANT MASTER FUND LTD</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>E9</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>1306313.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>1306313.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1306313.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>0.7</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>HAL MINTZ</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>FL</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>1306313.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>1306313.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1306313.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>0.7</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Tonix Pharmaceuticals Holding Corp.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>26 MAIN STREET, SUITE 101, 26 MAIN STREET, SUITE 101, CHATHAM, NEW JERSEY, 07928.</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Sabby Volatility Warrant Master Fund, Ltd.
Sabby Management, LLC
Hal Mintz</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>Sabby Volatility Warrant Master Fund, Ltd.
c/o Captiva (Cayman) Ltd
Governors Square, Bldg 4, 2nd Floor
23 Lime Tree Bay Avenue
P.O. Box 32315
Grand Cayman KY1-1209
Cayman Islands


Sabby Management, LLC
7012 Fisher Island Dr.
Miami Beach, FL 33109

Hal Mintz
c/o Sabby Management, LLC
7012 Fisher Island Dr.
Miami Beach, FL 33109
</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Sabby Volatility Warrant Master Fund, Ltd. - Cayman Islands
Sabby Management, LLC - Delaware, USA
Hal Mintz - USA</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>Sabby Volatility Warrant Master Fund, Ltd. -  1,306,313

Sabby Management, LLC -  1,306,313

Hal Mintz - 1,306,313</amountBeneficiallyOwned>
        <classPercent>Sabby Volatility Warrant Master Fund, Ltd. - 0.70%

Sabby Management, LLC - 0.70%

Hal Mintz - 0.70% </classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>0</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>1,306,313</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>1,306,313</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under &amp;#167; 240.14a-11.

</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>SABBY MANAGEMENT, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/S/ ROBERT GRUNDSTEIN</signature>
        <title>COO</title>
        <date>01/03/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>SABBY VOLATILITY WARRANT MASTER FUND LTD</reportingPersonName>
      <signatureDetails>
        <signature>/S/ ROBERT GRUNDSTEIN</signature>
        <title>COO OF INVESTMENT MANAGER</title>
        <date>01/03/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>HAL MINTZ</reportingPersonName>
      <signatureDetails>
        <signature>/S/ HAL MINTZ</signature>
        <title>HAL MINTZ</title>
        <date>01/03/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>