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Tonix Pharmaceuticals Holding Corp.

26 Main Street, Suite 101

Chatham, New Jersey 07928

 

September 3, 2025

 

VIA EDGAR

United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

 

  Re: Tonix Pharmaceuticals Holding Corp.
     
    Registration Statement on Form S-3 (File No. 333-287965)
     
    Filed on June 12, 2025

 

Ladies and Gentlemen:

 

In accordance with Rule 461 under the Securities Act of 1933, as amended, Tonix Pharmaceuticals Holding Corp. hereby requests that the above-referenced Registration Statement (the “Registration Statement”) be declared effective by the Securities and Exchange Commission at 4:30 p.m., Eastern Time, on September 4, 2025, or as soon as practicable thereafter.

 

Please call Irina Ishak of Lowenstein Sandler LLP at (973) 422-6406 to confirm the effectiveness of the Registration Statement or with any questions.

 

  Very truly yours,  
     
  TONIX PHARMACEUTICALS HOLDINGS CORP.
     
  By: /s/ Bradley Saenger  
  Name: Bradley Saenger  
  Title: Chief Financial Officer