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S-8 S-8 EX-FILING FEES 0001437402 ARDELYX, INC. N/A Fees to be Paid 0001437402 2025-10-31 2025-10-31 0001437402 1 2025-10-31 2025-10-31 iso4217:USD xbrli:pure xbrli:shares

Calculation of Filing Fee Tables

S-8

ARDELYX, INC.

Table 1: Newly Registered Securities

Security Type

Security Class Title

Fee Calculation Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

1 Equity Common stock, $0.0001 par value per share Other 10,000,000 $ 5.01 $ 50,100,000.00 0.0001381 $ 6,918.81

Total Offering Amounts:

$ 50,100,000.00

$ 6,918.81

Total Fee Offsets:

$ 0.00

Net Fee Due:

$ 6,918.81

Offering Note

1

(1) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement shall also cover any additional shares of the Registrant's common stock that become issuable under the Amended and Restated 2014 Equity Incentive Award Plan, as amended (the "Restated Plan"), by reason of any stock dividend, stock split, recapitalization or similar transaction effected without the Registrant's receipt of consideration which would increase the number of outstanding shares of common stock. (2) Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h) and Rule 457(c) promulgated under the Securities Act. The proposed maximum offering price per share and the proposed maximum aggregate offering price for shares reserved for future issuance under the Restated Plan are based on the average of the high and the low price of Registrant's Common Stock as reported on The Nasdaq Global Market on October 29, 2025. (3) Represents the additional shares of the Registrant's common stock available for issuance under the Restated Plan resulting from an increase approved by the Registrant's stockholders on June 18, 2025. (4) The Registrant does not have any fee offsets.

Table 2: Fee Offset Claims and Sources ☑Not Applicable
Registrant or Filer Name Form or Filing Type File Number Initial Filing Date Filing Date Fee Offset Claimed Security Type Associated with Fee Offset Claimed Security Title Associated with Fee Offset Claimed Unsold Securities Associated with Fee Offset Claimed Unsold Aggregate Offering Amount Associated with Fee Offset Claimed Fee Paid with Fee Offset Source
Rule 457(p)
Fee Offset Claims N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Fee Offset Sources N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A