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Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Checkbox not checked   Rule 13d-1(b)
Checkbox checked   Rule 13d-1(c)
Checkbox not checked   Rule 13d-1(d)




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SCHEDULE 13G




Comment for Type of Reporting Person:  The reporting persons beneficially own American Depositary Shares ("ADSs"). Each ADS represents 35 Ordinary Shares of the Issuer. The securities beneficially owned by the reporting persons consist of (1) 53,460 ADSs beneficially owned by the reporting persons, (2) pre-funded warrants to acquire 81,212 ADSs beneficially owned by the reporting persons, and (3) ordinary warrants to acquire 484,848 ADSs beneficially owned by the reporting persons. The pre-funded warrants and ordinary warrants are subject to a 9.99% beneficial ownership limitation. The percentage reported herein is calculated based on 70,294,615 Ordinary Shares, represented by 2,008,417 ADSs, outstanding as of May 5, 2026, as reported in the Form 10-Q for the quarter ended March 31, 2026, plus 1,400,000 Ordinary Shares represented by 40,000 issued to the reporting person on exercise of pre-funded warrants after December 5, 2025.


SCHEDULE 13G




Comment for Type of Reporting Person:  The reporting persons beneficially own ADSs. Each ADS represents 35 Ordinary Shares of the Issuer. The securities beneficially owned by the reporting persons consist of (1) 53,460 ADSs beneficially owned by the reporting persons, (2) pre-funded warrants to acquire 81,212 ADSs beneficially owned by the reporting persons, and (3) ordinary warrants to acquire 484,848 ADSs beneficially owned by the reporting persons. The pre-funded warrants and ordinary warrants are subject to a 9.99% beneficial ownership limitation. The percentage reported herein is calculated based on 70,294,615 Ordinary Shares, represented by 2,008,417 ADSs, outstanding as of May 5, 2026, as reported in the Form 10-Q for the quarter ended March 31, 2026, plus 1,400,000 Ordinary Shares represented by 40,000 issued to the reporting person on exercise of pre-funded warrants after December 5, 2025..


SCHEDULE 13G




Comment for Type of Reporting Person:  The reporting persons beneficially own ADSs. Each ADS represents 35 Ordinary Shares of the Issuer. The securities beneficially owned by the reporting persons consist of (1) 53,460 ADSs beneficially owned by the reporting persons, (2) pre-funded warrants to acquire 81,212 ADSs beneficially owned by the reporting persons, and (3) ordinary warrants to acquire 484,848 ADSs beneficially owned by the reporting persons. The pre-funded warrants and ordinary warrants are subject to a 9.99% beneficial ownership limitation. The percentage reported herein is calculated based on 70,294,615 Ordinary Shares, represented by 2,008,417 ADSs, outstanding as of May 5, 2026, as reported in the Form 10-Q for the quarter ended March 31, 2026, plus 1,400,000 Ordinary Shares represented by 40,000 issued to the reporting person on exercise of pre-funded warrants after December 5, 2025.


SCHEDULE 13G




Comment for Type of Reporting Person:  The reporting persons beneficially own ADSs. Each ADS represents 35 Ordinary Shares of the Issuer. The securities beneficially owned by the reporting persons consist of (1) 53,460 ADSs beneficially owned by the reporting persons, (2) pre-funded warrants to acquire 81,212 ADSs beneficially owned by the reporting persons, and (3) ordinary warrants to acquire 484,848 ADSs beneficially owned by the reporting persons. The pre-funded warrants and ordinary warrants are subject to a 9.99% beneficial ownership limitation. The percentage reported herein is calculated based on 70,294,615 Ordinary Shares, represented by 2,008,417 ADSs, outstanding as of May 5, 2026, as reported in the Form 10-Q for the quarter ended March 31, 2026, plus 1,400,000 Ordinary Shares represented by 40,000 issued to the reporting person on exercise of pre-funded warrants after December 5, 2025.


SCHEDULE 13G



 
Stonepine Capital Management, LLC
 
Signature:/s/ Jon M. Plexico
Name/Title:Managing Member
Date:05/15/2026
 
Stonepine Capital, L.P.
 
Signature:/s/ Jon M. Plexico
Name/Title:Managing Member of the General Partner, Stonepine GP, LLC
Date:05/15/2026
 
Stonepine GP, LLC
 
Signature:/s/ Jon M. Plexico
Name/Title:Managing Member
Date:05/15/2026
 
Jon M. Plexico
 
Signature:/s/ Jon M. Plexico
Name/Title:Reporting person
Date:05/15/2026
Exhibit Information

EXHIBIT 99 - AGREEMENT REGARDING JOINT FILING OF STATEMENT ON SCHEDULE 13D OR 13G