Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the reference to our firm under the caption “Experts” in this Registration Statement (Form S-3) (File No. 333-253485), as amended by this Amendment No. 1, and related Prospectus of Clovis Oncology, Inc. for the registration of common stock, preferred stock, warrants, and debt securities and to the incorporation by reference therein of our reports dated February 24, 2021, with respect to the consolidated financial statements of Clovis Oncology, Inc., and the effectiveness of internal control over financial reporting of Clovis Oncology, Inc., included in its Annual Report (Form 10-K) for the year ended December 31, 2020, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

Denver, Colorado

May 5, 2021