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Exhibit 22.1
Subsidiary Guarantors and Issuers of Guaranteed Securities

The following entities were, as of December 31, 2025, guarantors of IQVIA Inc.’s 5.700% Senior Secured Notes due 2028 and 6.250% Senior Secured Notes due 2029.
EntityRole
IQVIA Inc.Issuer
IQVIA Holdings Inc.Guarantor
Benefit Holding, Inc.Guarantor
BuzzeoPDMA LLCGuarantor
Clinical Financial Services, LLCGuarantor
Data Niche Associates, Inc.Guarantor
IMS Software Services Ltd.Guarantor
Innovex Merger Corp.Guarantor
Intercontinental Medical Statistics International, Ltd.Guarantor
IQVIA BioSciences Holdings, LLCGuarantor
IQVIA Biotech LLC Guarantor
IQVIA Commercial Finance Inc.Guarantor
IQVIA CSMS US Inc. Guarantor
IQVIA Digital Inc.Guarantor
IQVIA Government Solutions Inc. Guarantor
IQVIA Laboratories LLCGuarantor
IQVIA Pharma Inc.Guarantor
IQVIA Pharma Services Corp.Guarantor
IQVIA Phase One Services LLCGuarantor
IQVIA RDS Asia Inc.Guarantor
IQVIA RDS Inc.Guarantor
IQVIA RDS Latin America LLCGuarantor
IQVIA RDS Software Services LLCGuarantor
IQVIA Trading Management Inc.Guarantor
MCRA, LLCGuarantor
Med-Vantage, Inc.Guarantor
Outcome Sciences, LLCGuarantor
Q Squared Solutions (Quest) LLCGuarantor
Q Squared Solutions Holdings LLCGuarantor
QCare Site Services, Inc. Guarantor
Rules-Based Medicine Inc.Guarantor
RxJet Transportation Services Corp.Guarantor