<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001479419</cik>
        <entityName>KALA BIO, Inc.</entityName>
        <issuerAddress>
            <street1>1167 MASSACHUSETTS AVENUE</street1>
            <city>ARLINGTON</city>
            <stateOrCountry>MA</stateOrCountry>
            <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
            <zipCode>02476</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>781-996-5252</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>Kala Pharmaceuticals, Inc.</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>AVI</firstName>
                <lastName>MINKOWITZ</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1167 MASSACHUSETTS AVENUE</street1>
                <city>ARLINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02476</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Executive Officer, Chief Financial Officer and Director</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>DAVID</firstName>
                <lastName>LAZAR</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1167 MASSACHUSETTS AVENUE</street1>
                <city>ARLINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02476</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Director</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>HILLEL</firstName>
                <lastName>POSEN</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1167 MASSACHUSETTS AVENUE</street1>
                <city>ARLINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02476</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Director</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>CHAIM</firstName>
                <lastName>BERGER</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1167 MASSACHUSETTS AVENUE</street1>
                <city>ARLINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02476</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Director</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>YONATAN</firstName>
                <lastName>COLMAN</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1167 MASSACHUSETTS AVENUE</street1>
                <city>ARLINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02476</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Director</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>BRENDAN</firstName>
                <lastName>PURDY</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1167 MASSACHUSETTS AVENUE</street1>
                <city>ARLINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02476</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Director</relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2026-01-30</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>44905</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>FM Global Markets Inc.</recipientName>
                <recipientCRDNumber>000174843</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>130 ADELAIDE STREET WEST</street1>
                    <street2>SUITE 3002</street2>
                    <city>TORONTO</city>
                    <stateOrCountry>Z4</stateOrCountry>
                    <stateOrCountryDescription>CANADA (FEDERAL LEVEL)</stateOrCountryDescription>
                    <zipCode>M5H 3P5</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CO</state>
                    <description>COLORADO</description>
                    <state>DE</state>
                    <description>DELAWARE</description>
                    <state>FL</state>
                    <description>FLORIDA</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>WY</state>
                    <description>WYOMING</description>
                </statesOfSolicitationList>
                <foreignSolicitation>true</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>4200000</totalOfferingAmount>
            <totalAmountSold>2250600</totalAmountSold>
            <totalRemaining>1949400</totalRemaining>
            <clarificationOfResponse>The issuer issued 1,125,300 shares of Series AAA Preferred Stock at $2.00 per share for aggregate proceeds of $2,250,600 in a private placement pursuant to Rule 506(b) of Reg. D and 974,700 shares pursuant to Rule 903 of Reg. S.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>20</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>38988</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>KALA BIO, Inc.</issuerName>
                <signatureName>/s/ Avi Minkowitz</signatureName>
                <nameOfSigner>Avi Minkowitz</nameOfSigner>
                <signatureTitle>CEO, CFO and Director</signatureTitle>
                <signatureDate>2026-02-12</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>