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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Name of Issuer)

(Title of Class of Securities)

(CUSIP Number)

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13D/A 0001564590-22-023327 0001846370 XXXXXXXX LIVE 5 Ordinary Shares, nominal value of GBP0.05 per share 12/18/2024 false 0001479615 G8128Y157 Silence Therapeutics Plc 72 Hammersmith Road London X0 W14 8TH Richard Ian Griffiths 44-1534-719761 Floor 1 Liberation Station Esplanade St Helier Y9 JE2 3AS 0001846370 N Richard Ian Griffiths PF N Y9 27266001.00 0.00 27266001.00 0.00 27266001.00 N 19.3 IN Y Ora Capital Limited WC N Y9 19221525.00 0.00 19221525.00 0.00 19221525.00 N 13.6 CO Ordinary Shares, nominal value of GBP0.05 per share Silence Therapeutics Plc 72 Hammersmith Road London X0 W14 8TH Richard Ian Griffiths Floor 1 Liberation Station, Esplanade, St Helier, Jersey, JE2 4JD The principal business of Ora is capital investments. The principal business of Mr. Griffiths is serving as chairman of Sarossa Plc and Ora Limited. n/a n/a Jersey, Channel Islands Mr. Griffiths sold an aggregate of 23,064 ADSs in open market transactions between March 28, 2024 and December 10, 2024 for aggregate gross proceeds of $0.5M. Mr. Griffiths purchased an aggregate of 1,208,697 ADSs in open market transactions between March 28, 2024 and December 17, 2024 for an aggregate price of $11.6M. All purchases were for cash and were funded by companies or personal funds of Mr. Griffiths. This Amendment does not change the information previously reported under this item. (a)-(b) Rows (7) through (13) of the cover pages of this Schedule 13D are hereby incorporated by reference. N/A (c) Except as set forth in Schedule 1, none of the Reporting Persons has effected any transactions in shares of the Issuers Common Stock during the last 60 days. (d) No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, the shares of Common Stock beneficially owned by any of the Reporting Persons. N/A n/a A. Joint Filing Agreement as required by Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended. B. Schedule 1 Transactions in ADSs During the Past Sixty Days Richard Ian Griffiths /s/ Richard Ian Griffiths Richard Ian Griffiths 12/18/2024 Ora Capital Limited /s/ Richard Ian Griffiths Richard Ian Griffiths Director 12/18/2024