Exhibit 23.1

INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM’S CONSENT

We consent to the incorporation by reference in this Registration Statement of Soleno Therapeutics, Inc. on Form S-8 of our report dated February 28, 2025, with respect to our audits of the consolidated financial statements of Soleno Therapeutics, Inc. as of December 31, 2024 and 2023, and for each of the three years in the period ended December 31, 2024 and our report dated February 28, 2025 with respect to our audit of internal control over financial reporting of Soleno Therapeutics, Inc. as of December 31, 2024 appearing in the Annual Report on Form 10-K of Soleno Therapeutics, Inc. for the year ended December 31, 2024.

Our report on the effectiveness of internal control over financial reporting expressed an adverse opinion because of the existence of a material weakness.

 

/s/ Marcum LLP

Marcum LLP

San Francisco, CA

February 28, 2025