Subsidiary

Jurisdiction of Incorporation or Organization

Apellis Australia Pty Ltd.

Australia

Apellis Austria GmbH

Austria

Apellis Bermuda Ltd.

Bermuda

Apellis Canada Inc.

Canada

APL DEL Holdings, LLC

United States

Apellis Europe B.V.

Netherlands

Apellis Germany GmbH

Germany

Apellis France S.A.S.

France

Apellis International GmbH

Switzerland

Apellis Ireland Ltd.

Ireland

Apellis Italy S.r.I.

Italy

Apellis Netherlands, B.V.

Netherlands

Apellis Schweiz GmbH

Switzerland

Apellis Sweden AB

Sweden

Apellis U.K. Limited

United Kingdom

Apellis MA Securities, Inc.

United States

APL Sales I LLC

United States

APL PRG I Corporation

United States

APLSPRJ MRS, Inc.

United States