NAME:

JURISDICTION OF INCORPORATION:

  Horizon Medicines LLC

Delaware

  Horizon Ophthalmology, Inc

Delaware

  Horizon Orphan Holdings LLC

Delaware

  Horizon Orphan LLC

Delaware

  Horizon Properties Holding LLC

Delaware

  Horizon Therapeutics Brasil Ltda

Brazil

  Horizon Therapeutics Capital Limited

Ireland

  Horizon Therapeutics Finance Limited

Ireland

  Horizon Therapeutics Finance S.à.r.l

Luxembourg

  Horizon Therapeutics France SAS

France

  Horizon Therapeutics GmbH

Germany

  Horizon Therapeutics Holdings Limited

Ireland

  Horizon Therapeutics Investment Limited

Bermuda

  Horizon Therapeutics Ireland DAC

Ireland

  Horizon Therapeutics Italy S.r.l.

Italy

  Horizon Therapeutics Japan G.K.

Japan

  Horizon Therapeutics, LLC

Delaware

  Horizon Therapeutics Services LLC

Delaware

  Horizon Therapeutics Spain, S.L.

Spain

  Horizon Therapeutics Switzerland GmbH

Switzerland

  Horizon Therapeutics Treasury DAC

Ireland

  Horizon Therapeutics USA, Inc.

Delaware

  Hyperion Therapeutics Ireland Holding Limited

Ireland

  Hyperion Therapeutics Ireland Operating Limited

Ireland

  HZNP Canada Limited

Canada

  HZNP Finance Limited

Bermuda

  HZNP Limited

Ireland

  Viela Bio, Inc.

Delaware

  Viela Bio B.V.

Netherlands

  Viela Bio GmbH

Switzerland