| Item 1. | |
| (a) | Name of issuer:
Karyopharm Therapeutics Inc. |
| (b) | Address of issuer's principal executive offices:
85 Wells Avenue, 2nd Floor, Newton, Massachusetts, 02459 |
| Item 2. | |
| (a) | Name of person filing:
Each of the following is hereinafter individually referred to as a "Reporting Person" and collectively as the "Reporting Persons." This statement is filed on behalf of:
J. Wood Capital Advisors LLC
Jason Wood |
| (b) | Address or principal business office or, if none, residence:
The principal business address of each of the Reporting Persons is 1820 Calistoga Road, Santa Rosa, CA 95404. |
| (c) | Citizenship:
J. Wood Capital Advisors LLC is organized under the laws of the State of California. Jason Wood is a citizen of the United States. |
| (d) | Title of class of securities:
Common Stock, $0.0001 par value |
| (e) | CUSIP No.:
48576U205 |
| Item 3. | If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a: |
| (a) |  Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
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| (b) | Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
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| (c) | Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
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| (d) | Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
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| (e) | An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
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| (f) | An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
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| (g) | A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
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| (h) | A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
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| (i) | A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
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| (j) | A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
|
| (k) | Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
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| | |
| Item 4. | Ownership |
| (a) | Amount beneficially owned:
The ownership information presented below represents beneficial ownership of the shares of Common Stock, based upon 15,926,939 shares of Common Stock outstanding as of October 14, 2025, as disclosed in the Issuer's Current Report on Form 8-K filed with the Securities and Exchange Commission on October 14, 2025. The share amounts reported herein reflect a 1-for-15 reverse stock split of the Common Stock effected by the Issuer on February 24, 2025.
J. Wood Capital Advisors LLC is the record holder of 784,802 shares of Common Stock and 215,906 warrants to purchase an equal number of shares of Common Stock. The warrants contain a provision preventing exercise if such exercise would result in the Reporting Persons beneficially owning greater than 4.99% of the outstanding Common Stock when aggregated with all other shares of Common Stock beneficially owned. As a result, at any given time, the Reporting Persons may be deemed to beneficially own shares of Common Stock underlying the warrants only to the extent their total beneficial ownership does not exceed 4.99%.
Jason Wood is the managing member of J. Wood Capital Advisors LLC. As a result, Jason Wood may be deemed to share beneficial ownership of the shares of Common Stock directly held by J. Wood Capital Advisors LLC. |
| (b) | Percent of class:
4.99% |
| (c) | Number of shares as to which the person has:
|
| | (i) Sole power to vote or to direct the vote:
0
|
| | (ii) Shared power to vote or to direct the vote:
1,000,708
|
| | (iii) Sole power to dispose or to direct the disposition of:
0
|
| | (iv) Shared power to dispose or to direct the disposition of:
1,000,708
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| Item 5. | Ownership of 5 Percent or Less of a Class. |
| | 
Ownership of 5 percent or less of a class
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| Item 6. | Ownership of more than 5 Percent on Behalf of Another Person. |
| |
Not Applicable
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| Item 7. | Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person. |
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Not Applicable
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| Item 8. | Identification and Classification of Members of the Group. |
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Not Applicable
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| Item 9. | Notice of Dissolution of Group. |
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Not Applicable
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