Exhibit 15.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

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We consent to the incorporation by reference in the following Registration Statements of VNET Group, Inc.:

i)    Form S-8 No. 333-177273, pertaining to the 2010 Share Incentive Plan;

ii)    Form S-8 No. 333-187695, pertaining to the 2010 Share Incentive Plan, as amended;

iii)    Form S-8 No. 333-197495, pertaining to the 2014 Share Incentive Plan;

iv)    Form S-8 No. 333-208121, pertaining to the 2014 Share Incentive Plan, as amended;

v)    Form S-8 No. 333-222521, pertaining to the 2014 Share Incentive Plan, as amended;

vi)    Form S-8 No. 333-251568, pertaining to the 2020 Share Incentive Plan; and

vii)    Form F-3 No. 333-240044.

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of our reports dated April 26, 2022, with respect to the consolidated financial statements of VNET Group, Inc. and the effectiveness of internal control over financial reporting of VNET Group, Inc., included in this Annual Report (Form 20-F) for the year ended December 31, 2021.

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/s/ Ernst & Young Hua Ming LLP

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Shanghai, People’s Republic of China

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April 26, 2022