Exhibit 15.1

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Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the registration statements (No. 333-214800, No. 333-244736 and No. 333-262615) on Form S-8 and the registration statement (No. 333-252680) on Form F-3 of our report dated April 28, 2022, with respect to the consolidated financial statements of GDS Holdings Limited and the effectiveness of internal control over financial reporting.

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