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EXHIBIT 21.1

The following are subsidiaries of the Company as of December 31, 2017. The names of other subsidiaries have been omitted as they would not, if considered in the aggregate as a single subsidiary, constitute a significant subsidiary pursuant to Item 601(b)(21)(ii) of Regulation S-K under the Securities Exchange Act of 1934, as amended.

Subsidiary		State of Organization		D/B/A
Accredo Health Group, Inc.		Delaware		Liberty Pennsylvania, Medco Health Solutions, Liberty Texas, Gentiva, Gentiva Health Services
Accredo Health, Incorporated		Delaware		None
AHG of New York, Inc.		New York		None
Bio Partners In Care, Inc.		Missouri		None
CareCore National, LLC		New York		eviCore healthcare
CuraScript, Inc.		Delaware		CuraScript SP Specialty Pharmacy
Diversified Pharmaceutical Services, Inc.		Minnesota		None
ESI Canada		Ontario, Canada		None
ESI Mail Order Processing, Inc.		Delaware		None
ESI Mail Pharmacy Service, Inc.		Delaware		ESI Distribution Services, Express Scripts
ESI Partnership		Delaware		None
ESI Resources, Inc.		Minnesota		None
ESI-GP Holdings, Inc.		Delaware		None
eviCore healthcare MSI, LLC		Tennessee		eviCore healthcare
Express Scripts Administrators, LLC		Delaware		Express Scripts
Express Scripts Canada Co.		Nova Scotia, Canada		None
Express Scripts Canada Holding, Co.		Delaware		None
Express Scripts Pharmaceutical Procurement, LLC		Delaware		None
Express Scripts Pharmacy, Inc.		Delaware		Catamaran Home Delivery, Express Scripts
Express Scripts Sales Operations, Inc.		New Jersey		None
Express Scripts Services Company		Delaware		ESI/VRX Sales Development Co.
Express Scripts Specialty Distribution Services, Inc.		Delaware		Express Scripts Specialty Care
Express Scripts Strategic Development, Inc.		New Jersey		None
Express Scripts Utilization Management Co.		Delaware		None
Express Scripts, Inc.		Delaware		Express Scripts Administrators, Express Scripts Insurance Solutions
Lynnfield Drug, Inc.		Florida		Freedom Fertility Pharmacy, Hemophilia of the Sunshine State, Freedom Drug
MAH Pharmacy, L.L.C.		Delaware		CHD Pharmacy, Catalyst Mail, Catamaran Home Delivery, Meds at Home
Matrix GPO, LLC		Indiana		None
Medco Containment Insurance Company of New York		New York		None
Medco Containment Life Insurance Company		Pennsylvania		None
Medco Europe II, L.L.C.		Delaware		None
Medco Europe, L.L.C.		Delaware		None
Medco Health Puerto Rico, L.L.C.		Delaware		None
Medco Health Services, Inc.		Delaware		None

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Subsidiary		State of Organization		D/B/A
Medco Health Solutions, Inc.		Delaware		Medco Health, Medco Health Solutions, Express Scripts, Medco Health and Medco Health Solutions, Medco RX Discount Program, MHS Administrators of Rhode Island, Inc., Medco
Medco International Holdings B.V.		Netherlands		None
MHS Holdings, C.V.		Netherlands		None
Oz Parent, Inc.		Delaware		None
Priority Healthcare Corporation		Indiana		None
Priority Healthcare Distribution, Inc.		Florida		CuraScript SD Specialty Distribution
Strategic Pharmaceutical Investments, LLC		Delaware		None
Systemed, L.L.C.		Delaware		None