Exhibit 32.1

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CERTIFICATION

OF PRINCIPAL EXECUTIVE OFFICER AND

PRINCIPAL FINANCIAL OFFICER

PURSUANT TO 18 U. S. C. SECTION 1350,

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In connection with the Annual Report of DarioHealth Corp. (the “Company”) on Form 10-K for the period ended December 31, 2025 (the “Report”), I, Erez Raphael, Chief Executive Officer of the Company, and I, Chen Franco-Yehuda, Chief Financial Officer of the Company, hereby certify pursuant to 18 U.S.C. Section 1350, that to my knowledge:

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1.    The Report fully complies with the requirements of Section 13(a) or 15(d), as applicable, of the Securities Exchange Act of 1934; and

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2.    The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

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