EXHIBIT 23.1

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CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Semler Scientific, Inc.

Santa Clara, California

We hereby consent to the incorporation by reference in the Registration Statements on Form S-3 (No. 333-280013) and Form S-8 (No. 333-198275, No. 333-198891, No. 333-207779, No. 333-263341 and 333-283009) of Semler Scientific, Inc. of our report dated February 28, 2025, relating to the financial statements which appear in this Annual Report on Form 10-K.

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