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Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Checkbox not checked   Rule 13d-1(b)
Checkbox checked   Rule 13d-1(c)
Checkbox not checked   Rule 13d-1(d)






SCHEDULE 13G





SCHEDULE 13G




Comment for Type of Reporting Person:  Based on 2,785,787 Ordinary Shares outstanding as of 09/24/2025 as reported by Sol-Gel Technologies Ltd on 09/25/2025, in its 2025 Proxy Statement.


SCHEDULE 13G





SCHEDULE 13G



 
Opaleye Management Inc.
 
Signature:/s/ James Silverman
Name/Title:President
Date:11/17/2025
 
Opaleye, L.P.
 
Signature:/s/ James Silverman
Name/Title:General Partner
Date:11/17/2025
 
James Silverman
 
Signature:/s/ James Silverman
Name/Title:Individually
Date:11/17/2025
Exhibit Information

Exhibit 99.1 Joint Filing Agreement by and among the reporting persons