Document

We hereby consent to the incorporation by reference in the Registration Statements on Form S-3 (No. 333-277169, 333-281273, 333-282230, 333-270656, 333-251958) and Form S-8 (No. 333-279024, 333-264163, 333-249313, 333-238582) of Summit Therapeutics Inc. of our report dated February 24, 2025 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in this Form 10-K.