Exhibit 15.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We consent to the incorporation by reference in the following Registration Statements:
| (1) | Registration Statements (Form F-3 Nos. 333-276826, 333-280658, 333-281863,333-284376 and 333-289034) of PolyPid Ltd. |
| (2) | Registration Statements (Form S-8 Nos. 333-239517, 333-271060, 333-277703, 333-280662 and 333-289570) pertaining to the Amended and Restated 2012 Share Option plan of PolyPid Ltd. |
of our report dated February 25, 2026, with respect to the consolidated financial statements of PolyPid Ltd. included in this Annual Report (Form 20-F) of PolyPid Ltd. for the year ended December 31, 2025.
| Haifa, Israel | /s/ Kost Forer Gabbay & Kasierer |
| February 25, 2026 | A Member of EY Global |