Exhibit 15.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

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We consent to the incorporation by reference in the registration statements No.333-260801 and No. 333-199451 on Form S-8, and registration statements No. 333-263166, No. 333-260775, and No. 333-248740 on Form F-3 of our reports dated March 29, 2023, with respect to the consolidated financial statements of ProQR Therapeutics N.V. and the effectiveness of internal control over financial reporting.

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/s/ KPMG Accountants N.V.

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Amstelveen, the Netherlands

March 29, 2023