Exhibit 23.1

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Consent of Independent Registered Public Accounting Firm

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We consent to the incorporation by reference in the registration statements (No. 333-210586, 333-224827, 333-231334, 333-232486 and 333-265241) on Form S-8 and (No. 333-233656, 333-260940, 333-237937, 333-248659, 333-252939, 333-269177, 333-271932 and 333-273882) on Form S-3 of our report dated February 29, 2024, with respect to the consolidated financial statements of Senseonics Holdings, Inc.

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/s/ KPMG, LLP

McLean, Virginia

February 29, 2024