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Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Checkbox not checked   Rule 13d-1(b)
Checkbox checked   Rule 13d-1(c)
Checkbox not checked   Rule 13d-1(d)






SCHEDULE 13G




Comment for Type of Reporting Person:  The figure in Item 11 is based upon 12,861,672 shares of Class A Common Stock, par value $0.0001 per share ("Common Stock") of OnKure Therapeutics, Inc. (the "Issuer") outstanding as of September 30, 2025, as disclosed in the Issuer's prospectus, filed with the U.S. Securities and Exchange Commission (the "SEC") on November 21, 2025.


SCHEDULE 13G




Comment for Type of Reporting Person:  The figure in Item 11 is based upon 12,861,672 shares of Common Stock of the Issuer outstanding as of September 30, 2025, as disclosed in the Issuer's prospectus, filed with the SEC on November 21, 2025.


SCHEDULE 13G




Comment for Type of Reporting Person:  The figure in Item 11 is based upon 12,861,672 shares of Common Stock of the Issuer outstanding as of September 30, 2025, as disclosed in the Issuer's prospectus, filed with the SEC on November 21, 2025.


SCHEDULE 13G




Comment for Type of Reporting Person:  The figure in Item 11 is based upon 12,861,672 shares of Common Stock of the Issuer outstanding as of September 30, 2025, as disclosed in the Issuer's prospectus, filed with the SEC on November 21, 2025.


SCHEDULE 13G




Comment for Type of Reporting Person:  The figure in Item 11 is based upon 12,861,672 shares of Common Stock of the Issuer outstanding as of September 30, 2025, as disclosed in the Issuer's prospectus, filed with the SEC on November 21, 2025.


SCHEDULE 13G



 
Prosight Management, LP
 
Signature:Prosight Partners, LLC
Name/Title:General Partner
Date:11/28/2025
 
Signature:/s/ W. Lawrence Hawkins
Name/Title:Sole Manager of the General Partner
Date:11/28/2025
 
Prosight Fund, LP
 
Signature:Prosight Management, LP
Name/Title:General Partner
Date:11/28/2025
 
Signature:Prosight Partners, LLC
Name/Title:Sole Manager of the General Partner
Date:11/28/2025
 
Signature:/s/ W. Lawrence Hawkins
Name/Title:Sole Manager of the General Partner of the General Partner
Date:11/28/2025
 
Prosight Plus Fund, LP
 
Signature:Prosight Management, LP
Name/Title:General Partner
Date:11/28/2025
 
Signature:Prosight Partners, LLC
Name/Title:General Partner of the General Partner
Date:11/28/2025
 
Signature:/s/ W. Lawrence Hawkins
Name/Title:Sole Manager of the General Partner of the General Partner
Date:11/28/2025
 
Prosight Partners, LLC
 
Signature:/s/ W. Lawrence Hawkins
Name/Title:Sole Manager
Date:11/28/2025
 
W. Lawrence Hawkins
 
Signature:/s/ W. Lawrence Hawkins
Name/Title:W. Lawrence Hawkins
Date:11/28/2025
Exhibit Information

Exhibit 99.1: Joint Filing Agreement (filed herewith).