X0206 3 2022-02-14 1 0001621443 Zynerba Pharmaceuticals, Inc. ZYNE 0001750079 Parker Albert P C/O ZYNERBA PHARMACEUTICALS, INC. 80 W. LANCASTER AVENUE, SUITE 300 DEVON PA 19333 0 1 0 0 Chief Legal Officer /s/ Albert P. Parker 2022-02-15