X0306 4 2022-02-14 0001621443 Zynerba Pharmaceuticals, Inc. ZYNE 0001750079 Parker Albert P C/O ZYNERBA PHARMACEUTICALS, INC. 80 W. LANCASTER AVENUE, SUITE 300 DEVON PA 19333 0 1 0 0 Chief Legal Officer Common Stock 2022-02-14 4 A 0 35000 0 A 35000 D Stock Option (right to buy) 2.70 2022-02-14 4 A 0 200000 0 A 2032-02-14 Common Stock 200000 200000 D The restricted stock award vests in 3 equal annual installments on the first, second, and third anniversaries of the date of grant, beginning on February 14, 2023. The stock option vests 25% on the first anniversary of the date of the grant, with the remainder vesting in 12 equal quarterly installments thereafter, subject to continued employment with the Company through the applicable vesting date. /s/ Albert P. Parker 2022-02-15