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<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001631487</cik>
        <entityName>CollPlant Biotechnologies Ltd</entityName>
        <issuerAddress>
            <street1>4 OPPENHEIMER, WEIZMANN SCIENCE PARK</street1>
            <city>REHOVOT</city>
            <stateOrCountry>L3</stateOrCountry>
            <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
            <zipCode>7670104</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>+972 73 232 5600</issuerPhoneNumber>
        <jurisdictionOfInc>ISRAEL</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>CollPlant Holdings Ltd.</previousName>
            <previousName>CollPlant Biotechnologies Ltd.</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Yehiel</firstName>
                <lastName>Tal</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>COLLPLANT BIOTECHNOLOGIES LTD</street1>
                <street2>4 Oppenheimer, Weizmann Science Park</street2>
                <city>Rehovot</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>7670104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Executive Officer and Interim Chairman of the Board of Directors</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Eran</firstName>
                <lastName>Rotem</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>COLLPLANT BIOTECHNOLOGIES LTD</street1>
                <street2>4 Oppenheimer, Weizmann Science Park</street2>
                <city>Rehovot</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>7670104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Deputy Chief Executive Officer and Chief Financial Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Oren</firstName>
                <lastName>Fahimipoor</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>COLLPLANT BIOTECHNOLOGIES LTD</street1>
                <street2>4 Oppenheimer, Weizmann Science Park</street2>
                <city>Rehovot</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>7670104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Vice President, Operations</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Philippe</firstName>
                <lastName>Bensimon</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>COLLPLANT BIOTECHNOLOGIES LTD</street1>
                <street2>4 Oppenheimer, Weizmann Science Park</street2>
                <city>Rehovot</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>7670104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Vice President, Regulatory Affairs and Quality Assurance</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jasmine</firstName>
                <lastName>Seror</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>COLLPLANT BIOTECHNOLOGIES LTD</street1>
                <street2>4 Oppenheimer, Weizmann Science Park</street2>
                <city>Rehovot</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>7670104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Vice President, Product Development</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bowman</firstName>
                <lastName>Bagley</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>COLLPLANT BIOTECHNOLOGIES LTD</street1>
                <street2>4 Oppenheimer, Weizmann Science Park</street2>
                <city>Rehovot</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>7670104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Vice President, Commercial North America</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bar</firstName>
                <lastName>Abelis</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>COLLPLANT BIOTECHNOLOGIES LTD</street1>
                <street2>4 Oppenheimer, Weizmann Science Park</street2>
                <city>Rehovot</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>7670104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Vice President, Legal</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Abraham</firstName>
                <lastName>Havron</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>COLLPLANT BIOTECHNOLOGIES LTD</street1>
                <street2>4 Oppenheimer, Weizmann Science Park</street2>
                <city>Rehovot</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>7670104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Elan</firstName>
                <lastName>Penn</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>COLLPLANT BIOTECHNOLOGIES LTD</street1>
                <street2>4 Oppenheimer, Weizmann Science Park</street2>
                <city>Rehovot</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>7670104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Joseph</firstName>
                <lastName>Zarzewsky</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>COLLPLANT BIOTECHNOLOGIES LTD</street1>
                <street2>4 Oppenheimer, Weizmann Science Park</street2>
                <city>Rehovot</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>7670104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Hugh</firstName>
                <lastName>Evans</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>COLLPLANT BIOTECHNOLOGIES LTD</street1>
                <street2>4 Oppenheimer, Weizmann Science Park</street2>
                <city>Rehovot</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>7670104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alisa</firstName>
                <lastName>Lask</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>COLLPLANT BIOTECHNOLOGIES LTD</street1>
                <street2>4 Oppenheimer, Weizmann Science Park</street2>
                <city>Rehovot</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>7670104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Health Care</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2026-07-06</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Series A warrants and series B warrants to purchase ordinary shares, including underlying ordinary shares upon exercise.</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>H.C. Wainwright &amp; Co., LLC</recipientName>
                <recipientCRDNumber>000000375</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>430 Park Avenue</street1>
                    <street2>3rd Floor</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10022</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>FL</state>
                    <description>FLORIDA</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>TX</state>
                    <description>TEXAS</description>
                </statesOfSolicitationList>
                <foreignSolicitation>true</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>10400000</totalOfferingAmount>
            <totalAmountSold>10400000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>Including the exercise price of ordinary shares underlying such warrants at an exercise price of $0.34. The total offering amount excludes placement agent warrants (see Item 15).</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>5</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>272000</dollarAmount>
                <isEstimate>true</isEstimate>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>Includes placement and management fees, $35,000 non-accountable expense allowance, reimbursement of up to $50,000 legal fees and $15,950 clearing expenses, and warrants exercisable upon shareholder approval for 458,824 ordinary shares at $0.425/share.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse>The Company intends to use net proceeds for general corporate purposes, including working capital, R&amp;D programs, and evaluating strategic business combinations and other strategic transactions, the amount of which cannot currently be estimated.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>CollPlant Biotechnologies Ltd</issuerName>
                <signatureName>/s/ Eran Rotem</signatureName>
                <nameOfSigner>Eran Rotem</nameOfSigner>
                <signatureTitle>Deputy Chief Executive Officer and Chief Financial Officer</signatureTitle>
                <signatureDate>2026-07-20</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>