UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 14A
Proxy Statement Pursuant to Section 14(a) of the
Securities Exchange Act of 1934
(Amendment No. )
Filed by the Registrant ☒
Filed by a Party other than the Registrant ☐
Check the appropriate box:
| ☐ | Preliminary Proxy Statement | 
| ☐ | Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) | 
| ☐ | Definitive Proxy Statement | 
| ☒ | Definitive Additional Materials | 
| ☐ | Soliciting Material under § 240.14a-12 | 
Metacrine, Inc.
(Name of Registrant as Specified in its Charter)
(Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)
Payment of Filing Fee (Check all boxes that apply):
| ☒ | No fee required. | 
| ☐ | Fee paid previously with preliminary materials. | 
| ☐ | Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11. | 
| 
 | Metacrine, Inc. Important Notice Regarding the Availability of Proxy Materials | |
| P.O. BOX 8016, CARY, NC 27512-9903 | 2022 Annual Meeting of Stockholders to be held on May 18, 2022 | |
| For stockholders of record as of March 29, 2022 | ||
| This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. This is not a ballot. You cannot use this notice to vote your shares. We encourage you to access and review all of the important information contained in the proxy materials before voting. | ||
| To view the proxy materials, and to obtain directions to attend the meeting, go to: www.proxydocs.com/MTCR | ||
| To vote your proxy while visiting this site, you will need the 12 digit control number in the box below. | ||
| Under United States Securities and Exchange Commission rules, proxy materials do not have to be delivered in paper. Proxy materials can be distributed by making them available on the internet. | ||
| 
 | ||||
|   | For a convenient way to view proxy materials and VOTE go to |   | ||
| www.proxydocs.com/MTCR | ||||
| 
 Have the 12 digit control number located in the shaded box above available | ||||
| when you access the website and follow the instructions. | ||||
| If you want to receive a paper or e-mail copy of the proxy material, you must request one. There is no charge to you for requesting a copy. In order to receive a paper package in time for this year’s meeting, you must make this request on or before May 06, 2022. | ||||
| To order paper materials, use one of the following methods. | ||||
| 
 
 INTERNET www.investorelections.com/MTCR 
 | 
 TELEPHONE (866) 648-8133 
 | 
 paper@investorelections.com 
 | ||||||||||
| 
 When requesting via the Internet or telephone you will need the 12 digit control number located in the shaded box above. | 
 * If requesting material by e-mail, please send a blank e-mail with the 12 digit control number (located above) in the subject line. No other requests, instructions OR other inquiries should be included with your e-mail requesting material. | |||||||||||
| Metacrine, Inc. | ||||||
| Meeting Materials: Notice of Meeting and Proxy Statement & Annual Report on Form 10-K | ||||||
| Meeting Type: Annual Meeting of Stockholders | ||||||
| Date: | Wednesday, May 18, 2022 | |||||
| Time: | 8:00 AM, Pacific Time | |||||
| Place: | Annual Meeting to be held via live webcast - please visit | |||||
| www.proxydocs.com/MTCR for more details. | ||||||
| You must register to attend the Annual Meeting online and/or participate at www.proxydocs.com/MTCR | ||||||
| 
 SEE REVERSE FOR FULL AGENDA 
 | ||||||
Metacrine, Inc.
2022 Annual Meeting of Stockholders
THE BOARD OF DIRECTORS RECOMMENDS A VOTE:
FOR ON PROPOSALS 1 AND 2
PROPOSAL
| 1. | Election of Class II Directors | 
1.01 Richard Heyman, Ph.D.
1.02 Ronald Evans, Ph.D.
| 2. | To ratify the selection of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2022 |