<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001638097</cik>
        <entityName>Entera Bio Ltd.</entityName>
        <issuerAddress>
            <street1>Kiryat Hadassah - Minray Building</street1>
            <street2>Fifth Floor</street2>
            <city>Jerusalem</city>
            <stateOrCountry>L3</stateOrCountry>
            <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
            <zipCode>9112002</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>972-2-532-7151</issuerPhoneNumber>
        <jurisdictionOfInc>ISRAEL</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Miranda</firstName>
                <lastName>Toledano</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Entera Bio Ltd.</street1>
                <street2>Kiryat Hadassah-Minray Bldg, Fifth Flr</street2>
                <city>Jerusalem</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>9112002</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Executive Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Haya</firstName>
                <lastName>Taitel</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Entera Bio Ltd.</street1>
                <street2>Kiryat Hadassah-Minray Bldg, Fifth Flr</street2>
                <city>Jerusalem</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>9112002</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Yonatan</firstName>
                <lastName>Malca</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Entera Bio Ltd.</street1>
                <street2>Kiryat Hadassah-Minray Bldg, Fifth Flr</street2>
                <city>Jerusalem</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>9112002</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Dana</firstName>
                <lastName>Yaacov-Garbeli</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Entera Bio Ltd.</street1>
                <street2>Kiryat Hadassah-Minray Bldg, Fifth Flr</street2>
                <city>Jerusalem</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>9112002</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Financial Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Geno</firstName>
                <middleName>J.</middleName>
                <lastName>Germano</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Entera Bio Ltd.</street1>
                <street2>Kiryat Hadassah-Minray Bldg, Fifth Flr</street2>
                <city>Jerusalem</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>9112002</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chairman of the Board</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Sean</firstName>
                <lastName>Ellis</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Entera Bio Ltd.</street1>
                <street2>Kiryat Hadassah-Minray Bldg, Fifth Flr</street2>
                <city>Jerusalem</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>9112002</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Steven</firstName>
                <middleName>D.</middleName>
                <lastName>Rubin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Entera Bio Ltd.</street1>
                <street2>Kiryat Hadassah-Minray Bldg, Fifth Flr</street2>
                <city>Jerusalem</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>9112002</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2026-07-28</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Pre-Funded Warrants, and underlying Ordinary Shares</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Leerink Partners LLC</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>53 State Street</street1>
                    <street2>40th Floor</street2>
                    <city>Boston</city>
                    <stateOrCountry>MA</stateOrCountry>
                    <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                    <zipCode>02109</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>AL</state>
                    <description>ALABAMA</description>
                    <state>AK</state>
                    <description>ALASKA</description>
                    <state>AZ</state>
                    <description>ARIZONA</description>
                    <state>AR</state>
                    <description>ARKANSAS</description>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>CO</state>
                    <description>COLORADO</description>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
                    <state>DE</state>
                    <description>DELAWARE</description>
                    <state>DC</state>
                    <description>DISTRICT OF COLUMBIA</description>
                    <state>WY</state>
                    <description>WYOMING</description>
                    <state>WI</state>
                    <description>WISCONSIN</description>
                    <state>WV</state>
                    <description>WEST VIRGINIA</description>
                    <state>WA</state>
                    <description>WASHINGTON</description>
                    <state>VA</state>
                    <description>VIRGINIA</description>
                    <state>VT</state>
                    <description>VERMONT</description>
                    <state>UT</state>
                    <description>UTAH</description>
                    <state>TX</state>
                    <description>TEXAS</description>
                    <state>TN</state>
                    <description>TENNESSEE</description>
                    <state>SD</state>
                    <description>SOUTH DAKOTA</description>
                    <state>SC</state>
                    <description>SOUTH CAROLINA</description>
                    <state>RI</state>
                    <description>RHODE ISLAND</description>
                    <state>PA</state>
                    <description>PENNSYLVANIA</description>
                    <state>OR</state>
                    <description>OREGON</description>
                    <state>OK</state>
                    <description>OKLAHOMA</description>
                    <state>OH</state>
                    <description>OHIO</description>
                    <state>ND</state>
                    <description>NORTH DAKOTA</description>
                    <state>NC</state>
                    <description>NORTH CAROLINA</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>NM</state>
                    <description>NEW MEXICO</description>
                    <state>NJ</state>
                    <description>NEW JERSEY</description>
                    <state>NH</state>
                    <description>NEW HAMPSHIRE</description>
                    <state>NV</state>
                    <description>NEVADA</description>
                    <state>NE</state>
                    <description>NEBRASKA</description>
                    <state>MT</state>
                    <description>MONTANA</description>
                    <state>MO</state>
                    <description>MISSOURI</description>
                    <state>MS</state>
                    <description>MISSISSIPPI</description>
                    <state>MN</state>
                    <description>MINNESOTA</description>
                    <state>MI</state>
                    <description>MICHIGAN</description>
                    <state>MA</state>
                    <description>MASSACHUSETTS</description>
                    <state>MD</state>
                    <description>MARYLAND</description>
                    <state>ME</state>
                    <description>MAINE</description>
                    <state>LA</state>
                    <description>LOUISIANA</description>
                    <state>KY</state>
                    <description>KENTUCKY</description>
                    <state>KS</state>
                    <description>KANSAS</description>
                    <state>IA</state>
                    <description>IOWA</description>
                    <state>IN</state>
                    <description>INDIANA</description>
                    <state>IL</state>
                    <description>ILLINOIS</description>
                    <state>ID</state>
                    <description>IDAHO</description>
                    <state>HI</state>
                    <description>HAWAII</description>
                    <state>GA</state>
                    <description>GEORGIA</description>
                    <state>FL</state>
                    <description>FLORIDA</description>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Evercore Group L.L.C.</recipientName>
                <recipientCRDNumber>000042405</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>55 East 52nd Street</street1>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10055</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>AL</state>
                    <description>ALABAMA</description>
                    <state>AK</state>
                    <description>ALASKA</description>
                    <state>AZ</state>
                    <description>ARIZONA</description>
                    <state>AR</state>
                    <description>ARKANSAS</description>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>CO</state>
                    <description>COLORADO</description>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
                    <state>DC</state>
                    <description>DISTRICT OF COLUMBIA</description>
                    <state>FL</state>
                    <description>FLORIDA</description>
                    <state>GA</state>
                    <description>GEORGIA</description>
                    <state>IL</state>
                    <description>ILLINOIS</description>
                    <state>IN</state>
                    <description>INDIANA</description>
                    <state>KS</state>
                    <description>KANSAS</description>
                    <state>KY</state>
                    <description>KENTUCKY</description>
                    <state>LA</state>
                    <description>LOUISIANA</description>
                    <state>MD</state>
                    <description>MARYLAND</description>
                    <state>MA</state>
                    <description>MASSACHUSETTS</description>
                    <state>MI</state>
                    <description>MICHIGAN</description>
                    <state>MO</state>
                    <description>MISSOURI</description>
                    <state>MT</state>
                    <description>MONTANA</description>
                    <state>NH</state>
                    <description>NEW HAMPSHIRE</description>
                    <state>NJ</state>
                    <description>NEW JERSEY</description>
                    <state>NC</state>
                    <description>NORTH CAROLINA</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>OH</state>
                    <description>OHIO</description>
                    <state>OK</state>
                    <description>OKLAHOMA</description>
                    <state>OR</state>
                    <description>OREGON</description>
                    <state>PA</state>
                    <description>PENNSYLVANIA</description>
                    <state>RI</state>
                    <description>RHODE ISLAND</description>
                    <state>PR</state>
                    <description>PUERTO RICO</description>
                    <state>SC</state>
                    <description>SOUTH CAROLINA</description>
                    <state>TX</state>
                    <description>TEXAS</description>
                    <state>VA</state>
                    <description>VIRGINIA</description>
                    <state>WA</state>
                    <description>WASHINGTON</description>
                    <state>WV</state>
                    <description>WEST VIRGINIA</description>
                    <state>WI</state>
                    <description>WISCONSIN</description>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Guggenheim Securities, LLC</recipientName>
                <recipientCRDNumber>000040638</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>330 Madison Avenue</street1>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10017</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Cantor Fitzgerald &amp; Co.</recipientName>
                <recipientCRDNumber>000000134</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>110 East 59th Street</street1>
                    <street2>4th Floor</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10022</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>LifeSci Capital, LLC</recipientName>
                <recipientCRDNumber>000168404</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>1700 Broadway</street1>
                    <street2>40th Floor</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10019</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Canaccord Genuity LLC</recipientName>
                <recipientCRDNumber>000001020</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>One Pennsylvania Plaza</street1>
                    <street2>Suite 2900</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10119</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>274999976</totalOfferingAmount>
            <totalAmountSold>274999976</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>Offering amount (rounded) reflects an aggregate of 122,961,215 Ordinary Shares and 11,842,695 Pre-Funded Warrants</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>53</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>13748625</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Entera Bio Ltd.</issuerName>
                <signatureName>/s/ Dana Yaacov-Garbeli</signatureName>
                <nameOfSigner>Dana Yaacov-Garbeli</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2026-08-12</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>