April 19, 2021

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attention: Katherine Bagley

Re:	Zymergen Inc. Registration Statement on Form S-1 (File No. 333-254612) Request for Acceleration of Effective Date

Dear Ms. Bagley:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Zymergen Inc. (the “Company”) hereby requests acceleration of the effective date of the above-referenced Registration Statement on Form S-l (File No. 333-254612) (the “Registration Statement”). We respectfully request that the Registration Statement becomes effective 4:00 p.m., Eastern Time, on April 21, 2021 (the “Effective Date”), or as soon as possible thereafter. Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Freshfields Bruckhaus Deringer US LLP, by calling Sarah Solum at (650) 575-3591.

	Very truly yours,

	Zymergen Inc.

	By:	/s/Enakshi Singh
		Enakshi Singh
		Chief Financial Officer

cc:	Nasreen Mohammed
	Doug Jones
	Dietrich King
		Securities and Exchange Commission

	Mina Kim
		Zymergen Inc.

	Pamela L. Marcogliese
		Freshfields Bruckhaus Deringer US LLP

	Rezwan D. Pavri
	Andrew T. Hill
	Andrew S. Gillman
		Wilson Sonsini Goodrich & Rosati, P.C.