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We consent to the incorporation by reference in Registration Statement Nos. 333-257622, 333-268954 and 333-279735 on Form S-3ASR and Nos. 333-239135, 333-254824, 333-263093, 333-270064, 333-277413 and 333-285216 on Form S-8 of our reports dated February 24, 2026, relating to the financial statements of Vaxcyte, Inc. and the effectiveness of Vaxcyte, Inc.'s internal control over financial reporting appearing in this Annual Report on Form 10-K for the year ended December 31, 2025.