Exhibit 13.1

​

CERTIFICATION

​

The certification set forth below is being submitted in connection with AC Immune SA’s annual report on Form 20-F for the year ended December 31, 2023 (the “Report”) for the purpose of complying with Rule 13a-14(b) or Rule 15d-14(b) of the Securities Exchange Act of 1934 (the “Exchange Act”) and Section 1350 of Chapter 63 of Title 18 of the United States Code.

​

Andrea Pfeifer, the Chief Executive Officer of AC Immune SA, certifies that, to the best of her knowledge:

​

1. the Report fully complies with the requirements of Section 13(a) or 15(d) of the Exchange Act; and

​

2. the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of AC Immune SA.

​

Date: March 14, 2024

​

​