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Exhibit 15.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in the Registration Statements on Form F‑3 (No. 333-253358) and Form S-8 (No. 333-260683, No. 333-238042, No. 333-214263 and No. 333-213737) of The Bank of N.T. Butterfield & Son Limited of our report dated February 23, 2022 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in this Form 20‑F.

/s/ PricewaterhouseCoopers Ltd.

Hamilton, Bermuda

February 23, 2022