Exhibit 21.1
List of Subsidiaries of
Sienna Biopharmaceuticals, Inc.
| Name | Jurisdiction of Incorporation or Organization | |
| Creabilis Holdings Limited | United Kingdom | |
| Creabilis S.A. | Luxembourg | |
| Sienna Biopharmaceuticals S.r.L. | Italy | |
| Creabilis UK Limited | United Kingdom | |
| Instructive Color, LLC | Delaware |