Exhibit 32.2
CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the Quarterly Report of Amylyx Pharmaceuticals, Inc. (the “Company”) on Form 10-Q for the period ending June 30, 2024 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that:
Date: August 8, 2024  | 
    
  | 
    By:  | 
    /s/ Justin B. Klee  | 
   
  | 
    
  | 
    
  | 
    Justin B. Klee  | 
   
  | 
    
  | 
    
  | 
    Co-Chief Executive Officer  |