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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Name of Issuer)

(Title of Class of Securities)

(CUSIP Number)

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13D/A 0001668159 XXXXXXXX LIVE 4 Common Stock, par value $0.0001 per share 05/07/2025 false 0001858848 87990A106 Tenaya Therapeutics, Inc. 171 Oyster Point Boulevard Suite 500 South San Francisco CA 94080 James Evangelista (415) 865-2050 1 Letterman Drive, Building D Suite DM-900 San Francisco CA 94129 0001668159 N The Column Group III, LP b WC N DE 0 4414720 0 4414720 4414720 N 2.7 PN All such shares are held of record by TCG III LP (as defined in Item 2(a) of the Original Schedule 13D). TCG III GP LP (as defined in Item 2(a) of the Original Schedule 13D) is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson, David Goeddel, a member of the Issuer's board of directors, and Tim Kutzkey are the managing partners of TCG III GP LP and may each be deemed to share voting, investment and dispositive power with respect to these securities. Based on 162,666,931 shares of Common Stock outstanding as of May 1, 2025, as reported by the Issuer in its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the Commission) on May 7, 2025 (the Form 10-Q). 0001668085 N The Column Group III-A, LP b WC N DE 0 4985570 0 4985570 4985570 N 3.1 PN All such shares are held of record by TCG III-A LP (as defined in Item 2(a) of the Original Schedule 13D). TCG III GP LP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson, David Goeddel, a member of the Issuer's board of directors, and Tim Kutzkey are the managing partners of TCG III GP LP and may each be deemed to share voting, investment and dispositive power with respect to these securities. Based on 162,666,931 shares of Common Stock outstanding as of May 1, 2025, as reported by the Issuer in the Form 10-Q. 0001790965 N The Column Group III GP, LP b AF N DE 0 9400290 0 9400290 9400290 N 5.8 PN Consists of (i) 4,414,720 shares held of record by TCG III LP and (ii) 4,985,570 shares held of record by TCG III-A LP. TCG III GP LP is the general partner of each of TCG III LP and TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson, David Goeddel, a member of the Issuer's board of directors, and Tim Kutzkey are the managing partners of TCG III GP LP and may each be deemed to share voting, investment and dispositive power with respect to these securities. Based on 162,666,931 shares of Common Stock outstanding as of May 1, 2025, as reported by the Issuer in the Form 10-Q. 0001931825 N The Column Group Opportunity III, LP b WC N DE 0 49313559 0 49313559 49313559 N 30.3 PN All such shares are held of record by TCG Opportunity III LP (as defined in Item 2(a) of the Original Schedule 13D). TCG Opportunity III GP LP (as defined in Item 2(a) of the Original Schedule 13D) is the general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. TCG Opportunity III GP LLC (as defined in Item 2(a) of the Original Schedule 13D) is the general partner of TCG Opportunity III GP LP and the ultimate general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson, David Goeddel, a member of the Issuer's board of directors, and Tim Kutzkey are the managing members of TCG Opportunity III GP LLC and may each be deemed to share voting, investment and dispositive power with respect to these securities. Excludes warrants to purchase 53,571,426 shares of Common Stock held by TCG Opportunity III LP which are not exercisable within 60 days of this Statement due to the Beneficial Ownership Limitations (as defined in Item 6). Based on 162,666,931 shares of Common Stock outstanding as of May 1, 2025, as reported by the Issuer in the Form 10-Q. 0001932874 N The Column Group Opportunity III GP, LP b AF N DE 0 49313559 0 49313559 49313559 N 30.3 PN All such shares are held of record by TCG Opportunity III LP. TCG Opportunity III GP LP is the general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. TCG Opportunity III GP LLC is the general partner of TCG Opportunity III GP LP and the ultimate general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson, David Goeddel, a member of the Issuer's board of directors, and Tim Kutzkey are the managing members of TCG Opportunity III GP LLC and may each be deemed to share voting, investment and dispositive power with respect to these securities. Excludes warrants to purchase 53,571,426 shares of Common Stock held by TCG Opportunity III LP which are not exercisable within 60 days of this Statement due to the Beneficial Ownership Limitations. Based on 162,666,931 shares of Common Stock outstanding as of May 1, 2025, as reported by the Issuer in the Form 10-Q. 0001932445 N TCG Opportunity III GP, LLC b AF N DE 0 49313559 0 49313559 49313559 N 30.3 OO All such shares are held of record by TCG Opportunity III LP. TCG Opportunity III GP LP is the general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. TCG Opportunity III GP LLC is the general partner of TCG Opportunity III GP LP and the ultimate general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson, David Goeddel, a member of the Issuer's board of directors, and Tim Kutzkey are the managing members of TCG Opportunity III GP LLC and may each be deemed to share voting, investment and dispositive power with respect to these securities. Excludes warrants to purchase 53,571,426 shares of Common Stock held by TCG Opportunity III LP which are not exercisable within 60 days of this Statement due to the Beneficial Ownership Limitations. Based on 162,666,931 shares of Common Stock outstanding as of May 1, 2025, as reported by the Issuer in the Form 10-Q. Common Stock, par value $0.0001 per share Tenaya Therapeutics, Inc. 171 Oyster Point Boulevard Suite 500 South San Francisco CA 94080 This Amendment No. 4 (this Amendment No. 4) supplements and amends the Schedule 13D relating to the Common Stock of the Issuer that was filed with the Commission on December 1, 2022 (the Initial Schedule 13D), as amended by Amendment No. 1 filed with the Commission on February 21, 2023, by Amendment No. 2 filed with the Commission on February 14, 2024 and Amendment No. 3 filed with the Commission on March 7, 2025 (the Initial Schedule 13D, together with all amendments thereto, the Original Schedule 13D). The securities originally reported on the Initial Schedule 13D were previously reported on a Schedule 13G filed with the Commission on February 11, 2022 (the Schedule 13G). The Schedule 13G was filed pursuant to Rule 13d-1(d) of the Securities Exchange Act. This Amendment No. 4 is being filed to update the aggregate percentage of the Issuer's Common Stock owned by the Reporting Persons solely due to dilution caused by, among other things, the Issuer's sales of additional shares of its Common Stock from time to time since the date of the filing of the Original Schedule 13D and not in connection with a disposition of any shares by the Reporting Persons. Such dilution resulted in a decrease of over one percent (1%) in the aggregate percentage ownership reported by the Reporting Persons in the Original Schedule 13D. Only those items that are reported are hereby amended; all other items reported in the Original Schedule 13D remain unchanged. Capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Original Schedule 13D. The information set forth in Item 2(a) of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 2(b) of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 2(c) of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 2(d) of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 2(e) of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 2(f) of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 3 of the Original Schedule 13D is incorporated herein by reference. The information set forth in Item 4 of the Original Schedule 13D is incorporated herein by reference. See Items 7-11 of the cover pages of this Amendment No. 4. See Items 7-11 of the cover pages of this Amendment No. 4. Except as reported in this Statement, none of the Reporting Persons has affected any transactions in the Issuer's securities within the past 60 days. Under certain circumstances set forth in the limited partnership agreements of each of TCG III LP, TCG III-A LP and TCG Opportunity III LP, the general partner and limited partners of TCG III LP, TCG III-A LP and TCG Opportunity III LP, as applicable, may be deemed to have the right to receive dividends from, or the proceeds from, the sale of shares of the Issuer owned by such entity of which they are a partner. Not applicable. The information set forth in Item 6 of the Original Schedule 13D is incorporated herein by reference. The Column Group III, LP /s/ James Evangelista, Attorney in Fact James Evangelista, Attorney in Fact 05/14/2025 The Column Group III-A, LP /s/ James Evangelista, Attorney in Fact James Evangelista, Attorney in Fact 05/14/2025 The Column Group III GP, LP /s/ James Evangelista, Attorney in Fact James Evangelista, Attorney in Fact 05/14/2025 The Column Group Opportunity III, LP /s/ James Evangelista, Attorney in Fact James Evangelista, Attorney in Fact 05/14/2025 The Column Group Opportunity III GP, LP /s/ James Evangelista, Attorney in Fact James Evangelista, Attorney in Fact 05/14/2025 TCG Opportunity III GP, LLC /s/ James Evangelista, Attorney in Fact James Evangelista, Attorney in Fact 05/14/2025