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SCHEDULE 13D/A 0001104659-21-138124 0001674324 XXXXXXXX LIVE 1 Common Stock, par value $0.0001 per share 11/14/2025 false 0001689375 29384C108 ENTRADA THERAPEUTICS, INC. ONE DESIGN CENTER PLACE SUITE 17-500 BOSTON MA 02210 Lauren A. Daniel (415) 993-8570 c/o 5AM Venture Management, LLC 4 Embarcadero Center, Suite 3110 San Francisco CA 94111 0001674324 N 5AM Ventures V, L.P. b WC N DE 0.00 2963066.00 0.00 2963066.00 2963066.00 N 7.8 PN 0001791889 N 5AM Partners V, LLC b AF N DE 0.00 2963066.00 0.00 2963066.00 2963066.00 N 7.8 OO 0001753000 N 5AM Opportunities I, L.P. b WC N DE 0.00 1093313.00 0.00 1093313.00 1093313.00 N 2.9 PN 0001790778 N 5AM Opportunities I (GP), LLC b AF N DE 0.00 1093313.00 0.00 1093313.00 0.00 N 2.9 OO 0001598549 N Andrew J. Schwab b AF N X1 0.00 4056379.00 0.00 4056379.00 4056379.00 N 10.6 IN 0001664281 N Kush Parmar b AF N X1 67470.00 4056379.00 67470.00 4056379.00 4123849.00 N 10.8 IN 0001219014 N Scott M. Rocklage b AF N X1 0.00 2963066.00 0.00 2963066.00 2963066.00 N 7.8 IN Common Stock, par value $0.0001 per share ENTRADA THERAPEUTICS, INC. ONE DESIGN CENTER PLACE SUITE 17-500 BOSTON MA 02210 This Amendment No. 1 (this "Amendment No. 1" or this "Schedule 13D/A") amends and supplements the statement on Schedule 13D originally filed with the Securities and Exchange Commission (the "SEC") on November 12, 2021 (as amended, the "Statement") by the Reporting Persons. Unless otherwise defined herein, capitalized terms used in this Amendment No. 1 shall have the meanings ascribed to them in the Statement. Unless amended or supplemented below, the information in the Statement remains unchanged. Rows 11 and 13 of each Reporting Person's cover page to this Schedule 13D/A set forth the aggregate number of shares of common stock and percentages of the shares of common stock beneficially owned by such Reporting Person and are incorporated by reference. The percentage set forth in each row 13 is based upon 38,219,232 shares of common stock outstanding as of October 31, 2025 as reported in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 6, 2025. The Reporting Persons' beneficial ownership of the Issuer's common stock consists of (i) 2,963,066 shares of common stock directly held by 5AM V; (ii) 1,093,313 shares of common stock directly held by 5AM Opportunities; and (iii) 67,470 vested stock options (right to buy) held by Dr. Parmar. 5AM Partners V is the sole general partner of 5AM V and shares voting and dispositive power over the securities held by 5AM Partners V. 5AM Opportunities GP is the sole general partner of 5AM Opportunities and shares voting and dispositive power over the securities held by 5AM Opportunities. Schwab and Drs. Parmar and Rocklage are the managing members of 5AM Partners V and share voting and dispositive power over the securities held by 5AM V. Schwab and Dr. Parmar are the managing members of 5AM Opportunities GP and share voting and dispositive power over the securities held by 5AM Opportunities. Rows 7 through 10 of each Reporting Person's cover page to this Schedule 13D/A set forth the number of shares of common stock as to which such Reporting Person has the sole or shared power to vote or direct the vote and sole or shared power to dispose or to direct the disposition and are incorporated by reference. On November 14, 2025, 5AM V sold an aggregate of 200,000 shares in open market transactions at prices ranging from $8.80 to $9.023 (weighted average sales price of $8.80 per share). Except as set forth above, none of the Reporting Persons has effected any transactions with respect to the securities of the Issuer during the past sixty days. No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, the securities beneficially owned by any of the Reporting Persons. Not Applicable. Exhibit 99.1 Joint Filing Agreement (incorporated by reference to Exhibit A to the Reporting Persons' Schedule 13D, filed with the SEC on November 12, 2021). 5AM Ventures V, L.P. /s/ Scott M. Rocklage By 5AM Partners V, LLC, its General Partner, By Scott M. Rocklage, Managing Member 11/18/2025 5AM Partners V, LLC /s/ Scott M. Rocklage By Scott M. Rocklage, Managing Member 11/18/2025 5AM Opportunities I, L.P. /s/ Kush Parmar By 5AM Opportunities I (GP), LLC, its General Partner, By Kush Parmar, Managing Member 11/18/2025 5AM Opportunities I (GP), LLC /s/ Kush Parmar By Kush Parmar, Managing Member 11/18/2025 Andrew J. Schwab /s/ Andrew J. Schwab Andrew J. Schwab 11/18/2025 Kush Parmar /s/ Kush Parmar Kush Parmar 11/18/2025 Scott M. Rocklage /s/ Scott M. Rocklage Scott M. Rocklage 11/18/2025