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Exhibit 21.1

Subsidiaries of the Registrant

The list below excludes subsidiaries in the same line of business (ownership and operation of commercial real estate) and includes the immediate parent of each excluded subsidiary. The list also excludes subsidiaries that in the aggregate, as a single subsidiary, would not constitute a significant subsidiary as of December 31, 2025. A total of 71 subsidiaries have been excluded.

SubsidiaryState of Incorporation/Formation
IIP Operating Partnership, LPDelaware
Innovative Industrial Properties, LPDelaware
IIPR, Inc.Maryland
IIP-GP 2 LLCDelaware