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Exhibit 31.1

CERTIFICATION PURSUANT TO RULES 13a-14(a) AND 15d-14(a) UNDER THE SECURITIES

EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO

SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Taylor Schreiber, certify that:

1.			I have reviewed this Annual Report on Form 10-K/A of Shattuck Labs, Inc.; and

2.			Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report.

Date:			May 1, 2025			By:			/s/ Dr. Taylor Schreiber
									Dr. Taylor Schreiber Chief Executive Officer (principal executive officer)